Unifiram Powder Product Description

Introduction

Unifiram powder is a synthetic compound classified as a nootropic agent, developed for research purposes primarily related to cognitive enhancement. It is chemically distinct from traditional racetams despite similar effects on cognition. Unifiram is known by the research code DM-232 and exists as a fine white to off-white powder. It is used in scientific studies investigating memory, learning, and neuropharmacology, but is not approved for human consumption or therapeutic use.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C13H15FN2O3S

• Molecular Weight: 298.33 g/mol

• CAS Number: 272786-64-8

• IUPAC Name: 2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one

• Synonyms: DM-232

Physical Properties and Purity Standards

• Appearance: Pure white to off-white powder

• Purity: Typically supplied at a minimum of 98-99% for research-grade material

• Solubility: Soluble in dimethyl sulfoxide (DMSO), dimethylformamide (DMF), ethanol, and moderately soluble in DMSO/PBS mixtures; water solubility is limited

• Storage Recommendations: Store powdered Unifiram in a cool, dry place preferably at -20°C or below; avoid repeated freeze-thaw cycles. Stock solutions should be refrigerated and used within recommended times to maintain stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Unifiram acts as a potent AMPAkine-like agent influencing glutamatergic neurotransmission by modulating AMPA receptors. It significantly increases acetylcholine release in the cerebral cortex in vivo, which is closely linked to enhanced synaptic plasticity, memory formation, and cognitive function. Unlike many nootropics, Unifiram shows no significant binding affinity at serotonin, dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at typical research concentrations, indicating highly selective excitatory modulation through AMPA receptor pathways.

Research Applications

Unifiram is employed in neuroscience research to explore mechanisms of memory enhancement and anti-amnesic effects. It is part of studies involving animal behavioral models to investigate cognition, learning, and memory impairments such as those induced by antagonists in various receptor systems. Its exceptional potency compared to racetams like piracetam makes it valuable for research into novel treatments for cognitive disorders such as Alzheimer’s disease and dementia.

Comparative Analysis with Related Compounds

Comparison to Sunifiram and Racetams

Unifiram is structurally related to Sunifiram but is chemically distinct from traditional racetams due to its sulfonyl-phenyl group and unique hexahydropyrrolo-pyrazinone core. Both Unifiram and Sunifiram exhibit greater potency for cognitive enhancement in animal models than classical racetams like piracetam and phenylpiracetam. Their mechanisms converge on modulation of AMPA receptors but differ structurally and pharmacokinetically.

Advantages for Research

Unifiram offers significantly enhanced nootropic potency with a distinct chemical scaffold enabling highly selective receptor modulation. This specificity aids in dissecting glutamatergic involvement in cognition and memory. Its high efficacy at low doses makes it suitable for detailed mechanistic studies and development of novel neuroenhancers.

Safety and Handling Guidelines

Laboratory Safety

Use personal protective equipment including gloves, lab coat, and safety goggles when handling Unifiram powder. Avoid inhalation or ingestion; handle in well-ventilated areas or biosafety cabinets. Researchers should observe regulations concerning potent experimental chemicals.

Disposal and Environmental Considerations

Dispose of Unifiram waste according to institutional hazardous chemical waste protocols. Prevent environmental release and contamination by proper containment and disposal methods.

Regulatory Status

Unifiram is for research use only, not approved for human or veterinary applications. Regulatory status varies by jurisdiction, and it may be controlled or restricted due to its pharmacological potency. Confirm local regulations before acquisition or use.

Frequently Asked Questions (FAQs)

1. What is the primary use of Unifiram powder in research?
   It is used to study cognitive enhancement mechanisms, memory improvement, and neuropharmacology related to AMPA receptor modulation.

2. How does Unifiram compare to other nootropics like piracetam?
   Unifiram is significantly more potent and has a different chemical structure, working mainly through AMPA receptor activation and acetylcholine release.

3. Is Unifiram safe for human consumption?
   No, it is strictly for laboratory research and not approved for human use.

4. What are the recommended storage conditions for Unifiram?
   Store in a sealed container at -20°C or colder, protecting from moisture and light. Use prepared solutions promptly.

5. What solvents are suitable for dissolving Unifiram powder?
   Common solvents include DMSO, DMF, and ethanol, with limited solubility in water or PBS mixtures.

Conclusion

Unifiram powder is a research-grade nootropic compound with a unique chemical structure and potent pharmacological profile centered on glutamatergic AMPA receptor modulation and acetylcholine release enhancement. It serves as a valuable tool in cognitive research, offering superior potency compared to classical racetams. Due to its experimental status, Unifiram requires careful handling, proper storage, and adherence to regulatory guidelines. Its study continues to advance understanding of novel cognitive enhancement pathways.