RGPU-95 (p-Cl-Phenylpiracetam)

PRODUCT DESCRIPTION

Introduction

RGPU-95, also known as p-chlorophenylpiracetam, is a synthetic nootropic compound belonging to the racetam family, structurally derived from phenylpiracetam. It is characterized by the addition of a para-chloro substituent on the phenyl ring of phenylpiracetam. Developed by Russian researchers, RGPU-95 has attracted attention for its potential neuropharmacological properties, including antidepressant and anxiolytic effects as observed in preclinical studies. The compound is often supplied as a white or off-white powder with high purity for research purposes and is not approved for medical use.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C1212H1313ClN22O22

• Molecular Weight: 252.7 g/mol

• CAS Number: 213178-69-9

• IUPAC Name: 2-(4-(4-chlorophenyl)-2-oxopyrrolidin-1-yl)acetamide

• Synonyms: p-chlorophenylpiracetam, 2-oxo-4-(4-chlorophenyl)pyrrolidine-1-acetamide, 2-[4-(4-chlorophenyl)-2-oxopyrrolidin-1-yl]acetamide

Physical Properties and Purity Standards

• Appearance: White or off-white powder

• Purity: Typically ≥98% for research-grade material

• Solubility: Soluble in common organic solvents, solubility in aqueous media may be limited

• Storage Recommendations: Store in a cool, dry place, preferably refrigerated or at controlled room temperature to maintain stability and prevent degradation.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

RGPU-95 acts as a nootropic agent, likely exerting its effects through modulation of neurotransmitter systems, particularly those involved with cognitive function and mood regulation. Although the precise mechanism remains under investigation, it is related to racetams that typically modulate glutamatergic neurotransmission and may enhance neuroplasticity and synaptic transmission. RGPU-95 is reported to possess higher potency than phenylpiracetam in animal models, suggesting a stronger central nervous system stimulant and neuro-enhancing effect.

Research Applications

Researchers use RGPU-95 to explore neuroprotective, cognitive-enhancing, anxiolytic, and antidepressant effects in preclinical models. Its potential benefits for memory, learning, and mood disorders make it of interest in experimental neuropharmacology. RGPU-95 also serves as a model compound to understand structure-activity relationships within the racetam class and novel psychoactive substances (NPS).

Comparative Analysis with Related Compounds

Comparison with Phenylpiracetam

RGPU-95 is structurally similar to phenylpiracetam but includes a chlorine atom on the phenyl ring which increases its potency and possibly alters pharmacokinetics. Studies suggest RGPU-95 is 5 to 10 times more potent in activity compared to phenylpiracetam in animal models.

Advantages for Research

The increased potency and distinct chemical modification make RGPU-95 a valuable tool for studying enhanced effects in racetam-related nootropics. It provides insights into how halogen substitution impacts efficacy and receptor interactions which is critical for designing next-generation cognitive enhancers.

Safety and Handling Guidelines

Laboratory Safety

Handle RGPU-95 powder with appropriate personal protective equipment such as gloves, lab coats, and eye protection. Avoid inhalation of powder, skin contact, and ingestion. Use in a well-ventilated laboratory environment or fume hood.

Disposal and Environmental Considerations

Dispose of RGPU-95 waste according to hazardous chemical disposal regulations. Do not release into the environment; use approved hazardous waste protocols to prevent contamination.

Regulatory Status

RGPU-95 is classified as a research chemical and lacks approved medical indications. Its status as a novel psychoactive substance means regulatory control varies by jurisdiction, with restrictions often applied due to potential psychoactive effects.

Frequently Asked Questions (FAQs)

1. What is RGPU-95 used for in research?
   RGPU-95 is used to investigate cognitive enhancement, neuroprotection, and mood-related effects in animal and in vitro models.

2. How does RGPU-95 differ from phenylpiracetam?
   RGPU-95 has a chlorine substitution making it more potent and potentially altering pharmacokinetics compared with phenylpiracetam.

3. What solvents dissolve RGPU-95 effectively?
   RGPU-95 is soluble in organic solvents; specific solvent choice depends on the experimental protocol.

4. How should RGPU-95 be stored?
   Store RGPU-95 in a cool, dry environment, preferably refrigerated or at controlled room temperature.

5. Is RGPU-95 legal?
   Regulatory status varies; RGPU-95 is often controlled or restricted due to being a novel psychoactive substance.

Conclusion

RGPU-95 (p-chlorophenylpiracetam) is a potent racetam-class nootropic notable for its enhanced cognitive and neuropharmacological effects compared to phenylpiracetam. Its chemical stability, high purity, and unique structural features make it a significant research tool in the study of memory, mood disorders, and neuroprotection. Proper handling and adherence to regulatory guidelines are essential for its use in scientific investigations.