Proscaline Hydrochloride

PRODUCT DESCRIPTION

Introduction

Proscaline hydrochloride is the hydrochloride salt form of proscaline, a synthetic psychedelic phenethylamine known chemically as 4-propoxy-3,5-dimethoxyphenethylamine hydrochloride. Structurally related to mescaline and its analogues, proscaline produces psychedelic effects primarily by agonistic action on serotonin 5-HT2 receptors. The hydrochloride salt offers improved chemical stability and solubility, facilitating use in research environments studying psychedelics, receptor pharmacology, and neurochemistry.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C13H21NO3⋅HClC13H21NO3⋅HCl

• Molecular Weight: 275.77 g/mol

• CAS Number: 61367-69-9

• IUPAC Name: 4-propoxy-3,5-dimethoxyphenethylamine hydrochloride

• Synonyms: Proscaline HCl, 4-propoxy-3,5-DMPEA hydrochloride

Physical Properties and Purity Standards

• Appearance: White crystalline solid

• Purity: Typically ≥98% for research-grade material

• Solubility:

  • DMF: 0.5 mg/mL

  • DMSO: 3 mg/mL

  • Ethanol: 10 mg/mL

  • PBS (pH 7.2): 3 mg/mL

• Melting Point: 170-172 °C

• Storage Recommendations: Store sealed at -20°C under inert atmosphere to avoid degradation

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Proscaline hydrochloride acts as a potent agonist at serotonin 5-HT2 receptors, especially 5-HT2A, mediating its psychedelic effects which include altered perception, cognition, and hallucinations. Like other substituted phenethylamines, it modulates serotonergic neurotransmission, though detailed pharmacokinetic and metabolic data remain limited.

Research Applications

Commonly used in psychedelic research to explore receptor binding profiles, neuropsychopharmacology, and psychedelic structure-activity relationships. It also serves as a reference chemical in forensic and analytical studies.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Compared with free base proscaline, the hydrochloride salt improves water solubility and chemical stability, facilitating experimental protocols involving aqueous solutions or formulations. Structurally, it resembles mescaline with enhanced potency and duration.

Advantages for Research

The hydrochloride salt form is preferred for its physicochemical properties, ease of handling, and precise dosing in research contexts.

Safety and Handling Guidelines

Laboratory Safety

Use PPE including gloves and eye protection. Avoid inhalation of powders or vapors. Store safely to prevent environmental exposure or accidental ingestion.

Disposal and Environmental Considerations

Dispose of according to hazardous chemical waste protocols to prevent environmental hazards.

Regulatory Status

Proscaline hydrochloride is a research chemical, subject to regulatory control in many jurisdictions and not approved for human consumption.

Frequently Asked Questions (FAQs)

1. What is Proscaline hydrochloride used for?
   Psychedelic receptor and neuropharmacology research.

2. How soluble is the hydrochloride salt?
   Soluble in DMSO, ethanol, and buffered aqueous solutions.

3. What is the recommended storage?
   Sealed, refrigerated at -20°C, protected from moisture/light.

4. How does it differ from the free base?
   Better water solubility and chemical stability.

5. Are there safety precautions?
   Standard lab protocols for handling potent research chemicals.

Conclusion

Proscaline hydrochloride is a high-purity psychedelic phenethylamine hydrochloride salt optimized for research applications in serotonergic pharmacology. Its enhanced solubility and stability make it a preferred form for laboratory and analytical studies.