PPAP HCL (1-Phenyl-n-propylpentan-2-amine hydrochloride)

PRODUCT DESCRIPTION

Introduction

PPAP HCL (1-Phenyl-n-propylpentan-2-amine hydrochloride) is a synthetic psychoactive compound derived structurally from amphetamines and related to selegiline. It typically appears as a light brown to off-white powder or crystalline hydrochloride salt. Due to its structural modifications, PPAP HCL acts as a potent monoaminergic activity enhancer, modulating the release and reuptake of neurotransmitters such as dopamine and norepinephrine. It is primarily used in neuroscience research for studying psycho-stimulant mechanisms, synaptic transmission, and neuropharmacological activity.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C14H24ClNC14H24ClN

• Molecular Weight: 241.80 g/mol

• CAS Number: 119486-01-0

• IUPAC Name: 1-phenyl-N-propylpentan-2-amine hydrochloride

• Synonyms: PPAP hydrochloride, Phenylpropylaminopentane hydrochloride, 1-Phenyl-n-propylpentan-2-amine HCl

Physical Properties and Purity Standards

• Appearance: Light brown to off-white powder or crystalline salt

• Purity: Typically ≥98% pure for research-grade materials

• Solubility: Soluble in polar organic solvents like DMSO; limited aqueous solubility

• Storage Recommendations: Store sealed in a cool, dry place, protected from light, ideally at -20°C for long-term stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

PPAP HCL acts as a monoaminergic activity enhancer by stimulating the release of dopamine and norepinephrine neurotransmitters, and by inhibiting their reuptake to a modest degree. This leads to increased synaptic concentrations of these neurotransmitters, enhancing mood, focus, and cognitive alertness. PPAP is distinct from classical releasers as it modulates neurotransmission via action at multiple catecholaminergic sites without significant neurotoxicity.

Research Applications

Used primarily in neuropharmacological and psychostimulant research to investigate monoamine release mechanisms, synaptic plasticity, and neurochemical modulation. PPAP HCL is also useful in exploring the physiological effects of dopamine-enhancing agents and their therapeutic potential in mood and cognition deficits.

Comparative Analysis with Related Compounds

Compare to Related Compounds

PPAP is chemically related to selegiline and other amphetamine derivatives but is structurally unique due to the α-propyl substitution. It differs functionally from other phenethylamines by its distinct profile as a monoaminergic activity enhancer rather than a full releaser or uptake inhibitor. PPAP’s relatives include methylenedioxyphenylpropylaminopentane (MDPPP) and benzofuranylpropylaminopentane (BPAP).

Advantages for Research

PPAP presents a balanced enhancement of neurotransmitter release with low neurotoxicity, making it a valuable molecule for dissecting monoaminergic pathways and for potential neurotherapeutic applications.

Safety and Handling Guidelines

Laboratory Safety

Handle with gloves, lab coat, and eye protection in well-ventilated areas. Avoid inhalation, ingestion, and skin contact. Employ standard chemical safety procedures.

Disposal and Environmental Considerations

Dispose of unused compound and waste material according to hazardous chemical waste regulations.

Regulatory Status

PPAP HCL is for research use only, unapproved for medical or consumer use, and regulated under controlled substance and chemical research laws.

Frequently Asked Questions (FAQs)

1. What is PPAP HCL used for in research?
   Investigating monoaminergic modulation and psychostimulant mechanisms.

2. What is the solubility of PPAP HCL?
   Soluble in DMSO; limited water solubility.

3. How should PPAP HCL be stored?
   In sealed containers at low temperatures (-20°C), protected from moisture.

4. How does PPAP differ from amphetamines?
   PPAP is a monoaminergic activity enhancer, with balanced neurotransmitter modulation and lower toxicity.

5. Is it safe for laboratory handling?
   Yes, with typical chemical laboratory safety procedures.

Conclusion

PPAP HCL is a research-grade monoaminergic activity enhancer hydrochloride salt facilitating studies on dopamine and norepinephrine modulation. Its balanced pharmacology and structural uniqueness make it important in neuropharmacological investigations with standard safety and storage protocols.