NSI-189 Free Base

PRODUCT DESCRIPTION

Introduction

NSI-189 Free Base is a synthetic small molecule compound developed for research purposes, especially in neuroscience and neuropharmacology. It is presented as a crystalline solid, typically white to yellowish in color. NSI-189 belongs to a novel class of neurogenic compounds investigated for their ability to stimulate the growth of new neurons (neurogenesis) primarily in the hippocampus. It is chiefly used in preclinical and early clinical research for its potential in cognitive enhancement, neurogenesis stimulation, and treatment of neurological conditions like major depressive disorder (MDD) and cognitive impairment.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C22H30N4OC22H30N4O

• Molecular Weight: 366.5 g/mol

• CAS Number: 1270138-40-3

• IUPAC Name: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone

• Synonyms: CS-1018, NSI189, NSI-189 base, NSI-189 free base

Physical Properties and Purity Standards

• Appearance: A crystalline solid, color ranges from white to yellow

• Purity: Typically ≥98% pure for research-grade material

• Solubility: Soluble in DMSO and ethanol; low aqueous solubility

• Storage Recommendations: Store at -20°C in a cool, dry place protected from light to maintain stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

NSI-189 acts by stimulating hippocampal neurogenesis through mechanisms independent of classical monoamine pathways. It promotes proliferation and differentiation of neural stem cells into new neurons, potentially increasing hippocampal volume and synaptic plasticity. The compound has demonstrated neurotrophic and synaptoplastic properties, enhancing cognitive function and recovery in neurological conditions.

Research Applications

Widely used in neuroscience research, NSI-189 supports studies on major depressive disorder, cognitive impairment, stroke recovery, and other neurodegenerative diseases. It serves as a valuable tool for investigating neurogenesis stimulation, procognitive effects, and neuroprotective strategies in preclinical and clinical settings.

Comparative Analysis with Related Compounds

Compare to Related Compounds

NSI-189 is often compared with other neurogenic substances like fluoxetine and ketamine, which also modulate neuroplasticity but via different mechanisms. Unlike traditional antidepressants that mainly affect monoaminergic neurotransmission, NSI-189 specifically targets neural stem cell proliferation and hippocampal volume restoration.

Advantages for Research

NSI-189’s specificity for hippocampal neurogenesis and its non-monoaminergic mechanism make it a unique candidate for studying neuroplasticity and neurodegeneration. Its ability to promote synaptic remodeling offers advantages in researching treatments for depression, cognitive decline, and brain injury.

Safety and Handling Guidelines

Laboratory Safety

Handle NSI-189 with appropriate personal protective equipment including gloves, eye protection, and lab coats. Use in well-ventilated areas or fume hoods to avoid inhalation of powder. Avoid ingestion and skin contact.

Disposal and Environmental Considerations

Dispose of NSI-189 and related waste according to institutional hazardous waste protocols, ensuring no environmental contamination. Comply with local and national regulations regarding chemical disposal.

Regulatory Status

NSI-189 is an investigational compound not approved by the FDA for medical use. It is available exclusively for research purposes under controlled regulatory guidelines.

Frequently Asked Questions (FAQs)

1. What is NSI-189 used for in research?
   It is used mainly to study neurogenesis, cognitive enhancement, and neurodegenerative disease models.

2. Is NSI-189 approved for clinical use?
   No, it is an investigational compound restricted to research use only.

3. How soluble is NSI-189 Free Base?
   It is soluble in DMSO and ethanol but poorly soluble in water.

4. What storage conditions are recommended for NSI-189?
   Store at -20°C in a dark, dry place to preserve stability.

5. Are there known risks handling NSI-189?
   Standard laboratory safety precautions should be followed as long-term safety data is limited.

Conclusion

NSI-189 Free Base is a promising neurogenic research compound characterized by its ability to stimulate hippocampal neurogenesis and synaptic plasticity. With its well-defined chemical and physical properties, it facilitates advanced research into neurological disorders and cognitive enhancement. Proper handling and storage are essential due to its sensitive nature and investigational status.