MXPr (Methoxpropamine) Product Description

Introduction

Methoxpropamine (MXPr), also known as 2-(3-methoxyphenyl)-2-(propylamino)cyclohexanone, is a dissociative anesthetic research chemical belonging to the arylcyclohexylamine class. It is structurally related to ketamine, methoxetamine, and phencyclidine (PCP). MXPr typically appears as a white solid powder and has gained attention as a novel psychoactive dissociative agent. It is primarily used in pharmacological and toxicological research due to its NMDA receptor antagonist properties.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C16H23NO2

• Molecular Weight: 261.36 g/mol

• CAS Number: 2504100-71-2

• IUPAC Name: 2-(3-methoxyphenyl)-2-(propylamino)cyclohexanone

• Synonyms: MXPr, 3-methoxy-2-oxo-PCPr, 3-MeO-2′-OxO-PCPr

Physical Properties and Purity Standards

• Appearance: White solid powder

• Purity: Research grade, typically ≥98% purity

• Solubility: Soluble in organic solvents; limited data on water solubility

• Storage Recommendations: Store in a cool, dry, and dark place to preserve stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

MXPr acts primarily as an NMDA receptor antagonist, inhibiting glutamate neurotransmission in the central nervous system. This blockade leads to dissociative and anesthetic effects similar to those seen with ketamine and PCP.

Research Applications

• Neuroscience research to explore NMDA receptor function and dissociative pharmacology

• Investigation of novel psychoactive substances and their metabolism

• Toxicological studies and forensic identification

Comparative Analysis with Related Compounds

• Structurally similar to methoxetamine, ketamine, and PCP

• Unique propylamino substitution differentiates it from methoxetamine’s ethylamino group, creating distinct pharmacodynamic profiles

• Useful as a molecular variant to study structural modifications on NMDA receptor antagonism and dissociative actions

Safety and Handling Guidelines

Laboratory Safety

• Handle with gloves, eye protection, and proper ventilation to minimize exposure risk

• Toxicological data is limited; exercise caution

Disposal and Environmental Considerations

• Dispose according to hazardous chemical waste protocols

• Avoid environmental release due to potential bioactivity

Regulatory Status

• Legal status varies by jurisdiction

• Unscheduled at the US federal level but controlled in some countries (e.g., Finland)

• Confirm local regulations before use

Frequently Asked Questions (FAQs)

1. What is MXPr used for in research?
   It is mainly employed to study NMDA receptor antagonism and dissociative effects in neuroscience.

2. How does MXPr differ chemically from methoxetamine?
   MXPr has a propylamino group instead of methoxetamine’s ethylamino group, affecting its pharmacokinetics and receptor interactions.

3. Is it safe to handle MXPr in the lab?
   Use appropriate PPE and ventilation; limited safety data warrants caution.

4. What is the legal status of MXPr?
   It varies by jurisdiction; unscheduled federally in the US but regulated in some countries.

5. How should MXPr be stored?
   Keep in a cool, dry, dark place to maintain stability.

Conclusion

Methoxpropamine (MXPr) is a novel arylcyclohexylamine dissociative NMDA receptor antagonist with significant importance in dissociative pharmacology research. Its distinctive molecular structure facilitates investigations into psychoactive substances and neurotransmitter modulation, contributing valuable data to neuroscience and toxicology research.