Methaqualone (Quaalude) 300 mg Tablets Product Description

Introduction

Methaqualone, commonly known by the brand name Quaalude, is a sedative-hypnotic medication that was widely prescribed in the mid-20th century for anxiety, insomnia, and muscle relaxation. Each tablet contains 300 mg of methaqualone, delivering potent central nervous system depressant effects. Its use peaked in the 1960s and 1970s before being withdrawn in many countries due to widespread abuse and addiction concerns. Methaqualone acts primarily as a positive allosteric modulator of GABA-A receptors, producing sedation and muscle relaxation.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Name: 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

• Molecular Formula: C16H14N2O

• Molecular Weight: 250.29 g/mol

• CAS Number: 72-44-6

• Chemical Class: Quinazolinone derivative, sedative-hypnotic

Physical Form

• Appearance: White crystalline powder, formulated into oral tablets

• Dosage: 300 mg methaqualone per tablet

• Packaging: Commonly sold in blister packs or bottles containing multiple tablets

Pharmacological Profile and Mechanism of Action

• Methaqualone acts as a mixed positive allosteric modulator at various GABA-A receptor subtypes, enhancing the inhibitory neurotransmitter GABA’s effect

• Results in anxiolytic, sedative, hypnotic, and muscle relaxant effects with a pharmacodynamics profile similar to barbiturates but with a unique binding site

• Peak plasma concentrations are reached within a few hours, with an elimination half-life of 20-60 hours, contributing to its lasting effects

Indications and Usage

• Historically used for insomnia, anxiety, sedation before surgery, and muscle relaxation

• Due to high abuse potential, it has been withdrawn in most countries and is now mostly encountered in research or illicit contexts

Dosage and Administration

• Typical therapeutic dose: 300 mg orally as a single dose

• Not recommended for long-term use due to tolerance, dependence, and overdose risk

• Must be taken strictly under medical supervision

Storage and Handling

• Store tablets at controlled room temperature (20–25°C / 68–77°F)

• Protect from moisture and light

• Keep out of reach of children and unauthorized persons

Side Effects and Risks

• Common: Drowsiness, dizziness, impaired coordination

• Serious: Risk of overdose, dependence, tolerance, withdrawal symptoms, respiratory depression

• Similar overdose symptoms to barbiturates, but with increased motor impairment

Legal and Regulatory Status

• Classified as a Schedule I or controlled substance in many countries due to abuse potential

• Discontinued for medical use in most jurisdictions

Frequently Asked Questions (FAQs)

1. What is Methaqualone?
   A sedative-hypnotic drug formerly used for anxiety and insomnia.

2. What is the dosage of Quaalude tablets?
   Typically 300 mg per tablet.

3. Why was Methaqualone withdrawn?
   Due to high abuse, addiction, and overdose risks.

4. How does Methaqualone work in the brain?
   It potentiates GABA-A receptor activity causing CNS depression.

5. Is Methaqualone still legally available?
   No, it is mostly banned or controlled worldwide.

Conclusion

Methaqualone (Quaalude) 300 mg tablets were once widely prescribed for sedation and insomnia but are now restricted due to safety concerns and abuse potential. This sedative-hypnotic acts through modulation of GABA-A receptors and requires careful handling and regulatory compliance.