Flubromazepam 10mg Pellets Product Description

Introduction

Flubromazepam is a potent benzodiazepine derivative, structurally related to phenazepam, characterized by the presence of bromine and fluorine atoms. It exhibits strong sedative, anxiolytic, muscle relaxant, and hypnotic properties. Flubromazepam 10mg pellets are a solid dosage form designed for precise dosing in research. These pellets facilitate accurate experimentation in pharmacology and neurobiology focused on benzodiazepine receptor modulation.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H10BrFN2O

• Molecular Weight: 333.16 g/mol

• CAS Number: 2647-50-9

• IUPAC Name: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

• Synonyms: Flubromazepam, bromoflubromazepam, fluorophenazepam

2.2 Physical Properties and Pellet Specifications

• Appearance: White crystalline 10mg pellets

• Solubility: Soluble in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) at up to 25 mg/mL; soluble in ethanol (~10 mg/mL), methanol (~1 mg/mL), and 1:1 DMSO:phosphate-buffered saline (~0.5 mg/mL)

• Melting Point: 189–190°C

• Storage Recommendations: Store in airtight containers, in cool and dry conditions away from light to preserve efficacy and stability

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Flubromazepam functions as a high-affinity positive allosteric modulator at the GABA-A receptor benzodiazepine binding sites. This action enhances GABAergic inhibitory neurotransmission, leading to sedative, anxiolytic, muscle relaxant, and hypnotic effects. It is characterized by long duration of action and significant potency compared to many common benzodiazepines.

3.2 Research Applications

Primarily used in pharmacological research to investigate benzodiazepine receptor pharmacodynamics, CNS depression, and neurochemical effects. Pellet formulation supports consistent dosing and administration in animal models and preclinical investigations.

Comparative Analysis with Related Compounds

4.1 Comparison to Phenazepam and Other Benzodiazepines

Flubromazepam differs from phenazepam by substitution of the chlorine atom with fluorine, enhancing receptor affinity and potency. Compared to other benzodiazepines like diazepam or alprazolam, it typically exhibits longer duration and stronger effects, making it of interest for studying enhanced CNS depression.

4.2 Advantages for Research

Pellets provide reliable and reproducible dosing compared to powders or liquids. The 10mg dose per pellet is convenient for a wide range of experimental protocols in neuropharmacological research.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with personal protective equipment including gloves, lab coat, and eye protection. Perform all procedures in well-ventilated labs or under fume hoods.

5.2 Disposal and Environmental Considerations

Dispose of all waste materials according to chemical hazardous waste protocols. Prevent environmental contamination.

5.3 Regulatory Status

Flubromazepam is controlled or regulated in many jurisdictions and is for research use only. Compliance with legal and institutional policies is mandatory.

Frequently Asked Questions (FAQs)

1. What is the dosage in each Flubromazepam pellet?
   10mg per pellet.

2. What is the molecular weight of Flubromazepam?
   333.16 g/mol.

3. What solvents dissolve Flubromazepam?
   Soluble in DMF, DMSO, ethanol, and methanol.

4. What is the primary mechanism of Flubromazepam?
   Potentiation of GABA-A receptor activity at benzodiazepine sites.

5. What are typical research uses?
   Studying CNS depressant effects, benzodiazepine receptor pharmacology, anxiolytic mechanisms.

Conclusion

Flubromazepam 10mg pellets provide a potent and precise benzodiazepine dosage form for research into CNS depressant pharmacology. Their physical and chemical consistency, along with high potency, make them ideal for controlled experimental studies.