Flualprazolam Pure Product Description

Introduction

Flualprazolam is a potent triazolobenzodiazepine research chemical closely related to alprazolam, featuring fluorination which enhances its receptor affinity and pharmacological potency. It is known for strong sedative, anxiolytic, hypnotic, and muscle relaxant properties. Flualprazolam pure typically appears as a white or off-white crystalline powder, used exclusively in pharmaceutical and neuropharmacological research to explore benzodiazepine receptor interactions and central nervous system effects.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H12ClFN4

• Molecular Weight: 326.76 g/mol

• CAS Number: 28910-91-0

• IUPAC Name: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-triazolo[4,3-a]benzodiazepine

• Synonyms: Flualprazolam, fluorinated alprazolam, fluorinated triazolobenzodiazepine

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥99% pharmaceutical and research grade

• Solubility: Soluble in DMSO (~20 mg/mL), ethanol (~10 mg/mL), DMF (~30 mg/mL); partially soluble in aqueous buffers

• Storage Recommendations: Store in airtight containers in a cool, dry, dark place; refrigeration enhances shelf life

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Flualprazolam acts as a high-affinity positive allosteric modulator of the GABA-A receptor at benzodiazepine binding sites. It enhances GABAergic inhibitory neurotransmission leading to sedation, anxiolysis, muscle relaxation, and hypnotic effects. Fluorination contributes to increased receptor binding potency and potentially longer duration of action compared to alprazolam.

3.2 Research Applications

It is used extensively in neuropharmacological and toxicological research focusing on benzodiazepine receptor function, CNS depression mechanisms, and drug metabolism. Flualprazolam provides a tool for studying potent benzodiazepine receptor modulators and structure-activity relationships.

Comparative Analysis with Related Compounds

4.1 Comparison with Alprazolam

Flualprazolam exhibits higher receptor affinity and potentially stronger or longer-lasting effects compared to alprazolam due to its fluorination. Its chemical structure places it among designer benzodiazepines monitored for safety and abuse potential.

4.2 Advantages for Research

The pure crystalline form allows precise dosing and consistent experimental application. Its potent receptor modulation aids detailed exploration of benzodiazepine pharmacodynamics and pharmacokinetics.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use personal protective equipment including gloves and eye protection. Handle in properly ventilated labs and avoid inhalation or skin contact.

5.2 Disposal and Environmental Considerations

Dispose according to hazardous chemical waste guidelines to avoid environmental harm.

5.3 Regulatory Status

Flualprazolam is classified as a controlled research chemical not approved for human therapeutic use. Researchers must comply with applicable local regulations and institutional policies.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of Flualprazolam?
   326.76 g/mol.

2. What is the primary receptor target?
   GABA-A receptor benzodiazepine binding site.

3. How pure is research-grade Flualprazolam?
   ≥99%.

4. For what research is Flualprazolam commonly used?
   Studying benzodiazepine receptor pharmacology, CNS depressant effects.

5. How should Flualprazolam be stored?
   In airtight containers, cool, dry, and protected from light.

Conclusion

Flualprazolam pure is a high-purity fluorinated triazolobenzodiazepine with potent GABA-A receptor affinity. Its stability, high potency, and pharmacological profile make it a valuable research chemical for studying benzodiazepine mechanisms and CNS effects.