Alpha-PiHP (a-PiHP)

PRODUCT DESCRIPTION

Introduction

Alpha-PiHP (α-Pyrrolidinoisohexanophenone) is a synthetic stimulant compound categorized within the cathinone family and closely related to the pyrrolidinophenone subclass of novel psychoactive substances. It is a positional isomer of α-PHP, differing by the position of a methyl group on the alkyl side chain. Alpha-PiHP typically appears as an odorless, white to off-white crystalline powder or solid and is primarily utilized in research for pharmacological and forensic studies due to its potency and stimulant properties.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C16H23NO

• Molecular Weight: 245.36 g/mol

• CAS Number: Not specifically assigned distinct from α-PHP; related reference CAS numbers exist for synthetic cathinones

• IUPAC Name: 4-Methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one

• Synonyms:

  • α-PiHP

  • α-Pyrrolidinoisohexanophenone

  • a-PiHP

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder or solid

• Purity: Typically ≥98% for research-grade samples

• Solubility: Soluble in dimethyl sulfoxide (DMSO, 5 mg/mL), dimethylformamide (DMF, 3 mg/mL), ethanol (3 mg/mL), and phosphate buffer solution (1 mg/mL)

• Storage Recommendations: Store at low temperatures (-20°C) in airtight containers, protected from light and moisture to maintain compound stability and prevent degradation

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Alpha-PiHP acts as a potent reuptake inhibitor and releaser of the monoamine neurotransmitters dopamine and norepinephrine, with stimulant effects similar to other synthetic cathinones. It functions primarily by blocking dopamine and norepinephrine transporters, increasing extracellular neurotransmitter concentrations, and thereby enhancing central nervous system stimulation and euphoria. Its structural isomerism to α-PHP results in subtle differences in potency and metabolic profile.

3.2 Research Applications

This compound is employed in forensic and pharmacological research to study the mechanism of synthetic stimulants, profile metabolic products, and develop analytical methodologies for detection in biological samples. Alpha-PiHP provides valuable insights into structure-activity relationships among synthetic cathinone derivatives and their impact on monoaminergic systems.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

Alpha-PiHP is an isomer of α-PHP and a homologue of α-PVP, with differences primarily in the position and length of the alkyl side chain. These structural changes modulate pharmacokinetics and pharmacodynamics. Compared to α-PHP, α-PiHP may exhibit variance in receptor affinity and metabolic breakdown. Both compounds are part of a broader class including α-PVP, α-PBP, and other synthetic cathinones with stimulant profiles.

4.2 Advantages for Research

Alpha-PiHP’s chemically defined nature and high purity facilitate reproducible neurochemical and toxicological studies. Its distinctive positional isomerism enriches comparative research into how minor structural changes affect stimulant potency, toxicity, and metabolic fate. This aids in forensic identification and risk assessment of emerging substances.

Safety and Handling Guidelines

5.1 Laboratory Safety

Exercise caution handling alpha-PiHP using full PPE including gloves, lab coats, and eye protection. Employ fume hoods or well-ventilated environments to minimize inhalation exposure. Handle powders carefully to avoid aerosolization.

5.2 Disposal and Environmental Considerations

Disposal must comply with hazardous chemical waste regulations. Prevent environmental exposure by collecting and disposing of waste through authorized channels.

5.3 Regulatory Status

Alpha-PiHP is variably controlled internationally under synthetic cathinone regulatory frameworks or analog drug laws. It is recommended to verify local legislation prior to purchase or research use.

Frequently Asked Questions (FAQs)

1. What is alpha-PiHP?
   It is a positional isomer of α-PHP and a synthetic cathinone stimulant.

2. What is the molecular formula?
   C16H23NO.

3. How soluble is alpha-PiHP?
   Soluble in DMSO, DMF, ethanol, and buffers at low concentrations.

4. What effects does alpha-PiHP produce?
   It acts as a potent CNS stimulant by increasing dopamine and norepinephrine levels.

5. Is alpha-PiHP legally regulated?
   Yes, control varies by country; always verify regulations before use.

Conclusion

Alpha-PiHP is a potent, high-purity synthetic cathinone research chemical isomeric to α-PHP, providing important structural and pharmacological insights in psychoactive stimulant studies. Its precise chemical characterization supports forensic and toxicological applications with requisite safety and compliance measures.