6-APB 130mg Pellets

PRODUCT DESCRIPTION

Introduction

6-APB (6-(2-aminopropyl)benzofuran) is a synthetic empathogenic psychoactive compound belonging to the substituted benzofuran and substituted phenethylamine classes. It presents as solid pellets, here dosed at 130 mg per pellet, intended strictly for research purposes. Structurally, 6-APB features a benzofuran ring system replacing the methylenedioxyphenyl group found in related compounds such as MDA. It has been studied primarily for its psychoactive properties and interaction with monoamine neurotransmitter systems.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C11H13NO

• Molecular Weight: 175.23 g/mol

• CAS Number: 286834-85-3

• IUPAC Name: 1-(benzofuran-6-yl)propan-2-amine

• Synonyms:

  • 6-(2-Aminopropyl)benzofuran

  • 6-APB

  • Benzo Fury

2.2 Physical Properties and Purity Standards

• Appearance: Crystalline solid, often presented as pellets or powder; typically light tan to off-white in color

• Purity: ≥98% typical research grade standard

• Solubility: Soluble in DMSO, DMF, ethanol (up to 20 mg/mL), and moderately soluble in phosphate-buffered saline (PBS) at pH 7.2 (approximately 1 mg/mL)

• Storage Recommendations: Store in a cool, dry, light-protected environment at around -20°C to maintain compound integrity

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

6-APB acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA), showing potent release of these monoamines in neuronal synapses. It also functions as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with varying affinities for transporters: highest affinity for norepinephrine and dopamine transporters and relatively lower for serotonin transporter. These combined activities contribute to empathogenic and stimulant effects. 6-APB also displays agonist activity at serotonin receptors, notably 5-HT2A, implicated in psychedelic and entactogenic effects.

3.2 Research Applications

6-APB is used in pharmacological and neurochemical research to explore serotonergic, dopaminergic, and noradrenergic functional dynamics. Its unique benzofuran structure makes it a valuable compound for studying structure-activity relationships of substituted phenethylamines and benzofurans. Additionally, 6-APB serves as a subject in forensic toxicology to advance detection and metabolism studies of novel psychoactive substances.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

6-APB is closely related to 5-APB and MDA, but differs chemically by the presence of a benzofuran ring instead of the methylenedioxyphenyl group. The freebase is roughly 20% more potent than the hydrochloride salt form, and its effects differ accordingly. Compared to 5-APB, 6-APB has slightly different receptor affinities and pharmacokinetics due to positional isomerism on the benzofuran ring.

4.2 Advantages for Research

Its pellet form at 130 mg allows for accurate and reproducible dosing essential for laboratory studies. High purity and defined chemical properties make it suitable for in vitro receptor assays, in vivo neuropharmacological studies, and forensic standard development. The compound’s stability in solid pellet form facilitates ease of storage and handling.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle 6-APB pellets with gloves, eye protection, and lab coat in well-ventilated conditions or under a fume hood. Avoid inhalation and direct skin contact. Use tools to transfer pellets and prevent contamination.

5.2 Disposal and Environmental Considerations

Dispose of 6-APB and materials contaminated with it as hazardous chemical waste according to regulations. Avoid environmental discharge and exposure to water sources.

5.3 Regulatory Status

6-APB’s legal status varies globally; it is often controlled under analog laws or specific legislation due to its psychoactive properties. Confirm jurisdictional control before purchase or use.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of 6-APB?
   C11H13NO.

2. What research uses does 6-APB have?
   It is used for studying monoamine release, receptor binding, and novel psychoactive substance metabolism.

3. How soluble is 6-APB in common solvents?
   Soluble in DMSO, DMF, ethanol (~20 mg/mL), less so in buffered aqueous media (~1 mg/mL).

4. What are typical dosages for 6-APB research?
   Research dosages vary; pellets here contain 130 mg for precise dosing.

5. Is 6-APB regulated?
   Yes, regulatory status differs; verify local laws prior to use.

Conclusion

6-APB 130mg pellets offer a high-purity, stable empathogenic research chemical form with distinct serotonergic and monoaminergic activity. Their solid pellet dosage supports reproducible research applications in neuropharmacology and forensic science, with essential regulatory and safety protocols in place.