4F-MAR (4-Fluoro-4-methylaminorex) Product Description

Introduction

4F-MAR, also known as 4-Fluoro-4-methylaminorex or para-fluoro methylaminorex, is a synthetic stimulant and halogenated derivative of 4-methylaminorex (4-MAR). It features a fluorine atom at the para position of the phenyl ring and a methyl group on the oxazoline ring. First identified in forensic samples, 4F-MAR is an emerging novel psychoactive substance (NPS) known for stimulant and anorectic effects similar to other aminorex analogs.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White crystalline solid.

• Purity: ≥ 98% research-grade purity, with stability ≥5 years if stored at -20°C.

• Solubility: Soluble in polar organic solvents such as DMSO and ethanol.

• Storage: Store in airtight containers protected from light and moisture at low temperatures (-20°C).

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4F-MAR acts as a central nervous system stimulant by increasing synaptic levels of dopamine, norepinephrine, and serotonin via release and reuptake inhibition. The fluorine substitution on the phenyl ring influences its potency and metabolic stability compared to 4-MAR.

Research Applications

Used in forensic toxicology for NPS identification and neuropharmacological research to understand stimulant mechanism, pharmacokinetics, and toxicology.

Safety and Handling Guidelines

Laboratory Safety

Standard laboratory PPE required including gloves, lab coat, eye protection. Work in ventilated areas or fume hoods.

Disposal and Environmental Considerations

Dispose according to hazardous chemical waste protocols.

Regulatory Status

4F-MAR is usually controlled under NPS or analogue drug laws and authorized only for licensed research.

Frequently Asked Questions (FAQs)

1. What is the molecular formula?

• C10H11FN2O.

2. What are main effects?

• CNS stimulant with dopamine/norepinephrine/serotonin release.

3. What purity is guaranteed?

• ≥ 98% research-grade purity.

4. How soluble is 4F-MAR?

• Soluble in DMSO, ethanol, water (to a lesser extent).

5. How should it be stored?

• In airtight, light-protected containers at -20°C.

6. Is it legal?

• Regulated as a novel psychoactive substance, research-only use.

Conclusion

4F-MAR is a chemically stable, potent synthetic stimulant with significant forensic and neuropharmacological research applications. Its fluorine substitution imparts unique properties within the aminorex stimulant class.