4-AcO-MET Fumarate Product Description

Introduction

4-AcO-MET fumarate is the fumaric acid salt form of 4-Acetoxy-N-methyl-N-ethyltryptamine (4-AcO-MET), a synthetic psychedelic tryptamine related to psilocybin and psilocin. The fumarate salt provides enhanced chemical stability and crystallinity compared to freebase forms, making it suitable for precise dosing and research use. 4-AcO-MET acts as a prodrug, converting in vivo to the active metabolite 4-HO-MET, which produces classic psychedelic effects primarily through serotonin 5-HT2A receptor agonism.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: Off-white to white crystalline powder, often provided neat without excipients.

• Purity: Typically ≥ 95% (HPLC certified), with high purity validated by chromatography and spectroscopy.

• Solubility: Soluble in water, methanol, ethanol, and dimethyl sulfoxide (DMSO).

• Storage Recommendations: Store under refrigeration at -20°C in airtight, light-shielding containers for long-term stability.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4-AcO-MET fumarate functions as a serotonin 5-HT2A receptor agonist prodrug, metabolized in vivo to 4-Hydroxy-MET (4-HO-MET). It induces psychedelic effects including altered sensory perception, enhanced mood, and introspection. The fumarate salt form contributes to enhanced stability and formulation properties.

Research Applications

Widely used in neuropharmacological and behavioral research for studying psychedelic effects of tryptamine derivatives, receptor pharmacology, metabolism, and structure-activity relationships. It serves as a calibration standard for analytical methods and supports clinical research development.

Safety and Handling Guidelines

Laboratory Safety

Use suitable PPE including gloves, lab coat, and eye protection. Handle material within ventilated fume hoods to minimize exposure.

Disposal and Environmental Considerations

Dispose of chemical residues and waste in accordance with hazardous chemical waste protocols.

Regulatory Status

4-AcO-MET fumarate is regulated in various jurisdictions and limited to licensed research use.

Frequently Asked Questions (FAQs)

1. What is the active form of 4-AcO-MET fumarate?

• It metabolizes to 4-HO-MET, the active psychedelic.

2. What receptors does 4-AcO-MET affect?

• Primarily serotonin 5-HT2A receptors.

3. What is the typical purity of 4-AcO-MET fumarate?

• Approximately ≥ 95% by HPLC standards.

4. How should 4-AcO-MET fumarate be stored?

• At -20°C, in airtight, light-protected containers.

5. Is 4-AcO-MET fumarate legal?

• It is controlled and restricted to scientific research only.

Conclusion

4-AcO-MET fumarate is a high-purity fumaric acid salt form of the psychedelic prodrug 4-AcO-MET, utilized in neuropharmacological research for serotonin receptor-mediated psychedelic effects. Its fumarate salt form offers enhanced chemical stability and consistent dosing for advanced scientific applications.