2-FPM (2-Fluorophenmetrazine) Product Description

Introduction

2-FPM, or 2-Fluorophenmetrazine, is a synthetic stimulant belonging to the phenylmorpholine class. It is a fluorinated analog of phenmetrazine, characterized by the substitution of a fluorine atom at the second position of the phenyl ring. 2-FPM has emerged as a designer research chemical with stimulant properties akin to amphetamines and phenmetrazine-type substances. It is predominantly used in scientific research aiming to understand new psychoactive substances and their neuropharmacological effects.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C11H14FNO

• Molecular Weight: 195.23 g/mol

• CAS Number: Not widely assigned due to new research chemical designation

• IUPAC Name: 2-(2-fluorophenyl)-3-methylmorpholine

• Synonyms: 2-Fluorophenmetrazine, 2-FPM, 2-(2-Fluorophenyl)-3-methylmorpholine

Physical Properties and Purity Standards

• Appearance: White crystalline powder or flakes.

• Purity: Research-grade 2-FPM generally ≥ 98% purity.

• Solubility: Soluble in organic solvents such as ethanol, methanol, DMSO, and DMF; limited water solubility.

• Storage Recommendations: Store in airtight containers, protected from moisture and light, at cool temperatures preferably below -20°C.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2-FPM acts as a central nervous system stimulant by increasing extracellular levels of dopamine, norepinephrine, and serotonin through release promotion and reuptake inhibition. Fluorination at position 2 modifies its affinity for monoamine transporters, potentially altering potency, efficacy, and metabolic stability relative to phenmetrazine and related compounds. Behavioral assays indicate stimulant and reinforcing properties similar to amphetamines.

Research Applications

2-FPM serves as a research probe for studying monoamine transporter substrates and inhibitors, neuropharmacology of stimulants, and structure-activity relationship studies on newly emerging psychoactive substances. It is also useful for forensic and toxicological analysis due to its growing prevalence.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Compared to phenmetrazine, 2-FPM contains a fluorine substituent that influences pharmacokinetic properties and potentially reduces neurotoxicity. It contrasts with positional isomers such as 3-FPM and 4-FPM which vary in potency and pharmacological effects. It shares stimulant mechanisms with amphetamines but differs chemically as a morpholine derivative.

Advantages for Research

The fluorination offers improved metabolic stability and differentiated transporter affinity, enhancing its utility in transporter pharmacology and addiction research. Its novel structure facilitates diversity in stimulant pharmacology models and potential medicinal chemistry applications.

Safety and Handling Guidelines

Laboratory Safety

Use appropriate PPE (gloves, lab coat, eye protection). Handle in well-ventilated areas or fume hoods to minimize aerosol or contact exposure.

Disposal and Environmental Considerations

Dispose of in accordance with hazardous chemical waste regulations. Avoid environmental contamination by proper containment and neutralization measures.

Regulatory Status

2-FPM is regulated in some jurisdictions as a controlled substance or research chemical. Use is restricted to licensed scientific research facilities.

Frequently Asked Questions (FAQs)

1. What is 2-FPM used for in research?

• Investigating stimulant pharmacology, neurotransmitter transporter activity, and NPS characterization.

2. How does 2-FPM differ from phenmetrazine?

• It contains fluorine substitution, impacting pharmacokinetics and neuronal effects.

3. What solvents dissolve 2-FPM?

• Ethanol, methanol, DMSO, DMF, with limited water solubility.

4. How should 2-FPM be stored?

• Airtight, moisture-free containers at temperatures preferably below -20°C.

5. Is 2-FPM legal?

• It is controlled or regulated in multiple countries, for research use only.

Conclusion

2-Fluorophenmetrazine (2-FPM) is a research chemical stimulant within the phenylmorpholine class, notable for its fluorination which modulates pharmacological and metabolic profiles. It is valuable for neuropharmacological and toxicological research conducted under strict safety and regulatory controls.