Introduction

1V-LSD, also known as Valerie, is a synthetic lysergamide and a novel analog of LSD, characterized by a valeroyl (pentanoyl) group attached at the nitrogen-1 position of the lysergic acid diethylamide structure. Supplied as 225 microgram doses, 1V-LSD is intended for controlled scientific research and neuropharmacological exploration. Known for inducing profound psychedelic effects, 1V-LSD is a member of the substantial family of N-acylated LSD derivatives, often acting as a prodrug metabolizing in vivo to LSD.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C25H33N3O2

• Molecular Weight: Approximately 407.55 g/mol

• CAS Number: Not widely assigned (research chemical)

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-pentanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1V-LSD, Valerie, 1-Valeryl-LSD, 1-Pentanoyl-LSD

Physical Properties and Purity Standards

• Appearance: White to off-white crystalline substance, typically prepared in precise 225 mcg doses for controlled research use.

• Purity: Typically ≥ 98%, fitting research-grade chemical standards.

• Solubility: Soluble in organic solvents such as ethanol, methanol, and acetonitrile, with low water solubility.

• Storage Recommendations: Store sealed in cool, dark, dry conditions, preferably refrigerated to maintain stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1V-LSD is understood to function primarily as a prodrug to LSD, enzymatically metabolized in vivo to LSD, the principal active compound responsible for psychedelic effects. It activates serotonin 5-HT2A receptors, leading to the classic psychedelic profile. Animal studies demonstrate it has approximately one-third the potency of LSD in inducing typical psychedelic behaviors, such as the head-twitch response.

Research Applications

1V-LSD offers a unique tool for neuropharmacological research into serotonergic psychedelics, receptor binding, and pharmacokinetics. Its potent psychedelic effects and distinctive chemical structure allow detailed exploration of psychedelic mechanisms, microdosing regimens, and metabolic pathways.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Chemically, 1V-LSD differs from 1P-LSD and 1B-LSD in the length and hydrophobicity of the acyl chain at the nitrogen-1 position, which affects metabolism and potency. It is pharmacologically related to these compounds as a prodrug to LSD but presents distinct pharmacokinetic and receptor interaction profiles.

Advantages for Research

The 225 mcg dosage supports studies involving full-dose and higher-dose psychedelic effects, providing opportunities to explore cognitive, emotional, and perceptual alterations. Its prodrug nature and distinct chemical structure expand the scope of psychedelic research chemicals.

Safety and Handling Guidelines

Laboratory Safety

Always use appropriate PPE, including gloves, laboratory coat, and eye protection. Handle in well-ventilated areas or fume hoods to minimize exposure. Follow institutional safety guidelines rigorously.

Disposal and Environmental Considerations

Dispose of 1V-LSD waste according to hazardous chemical regulations. Prevent environmental release by appropriate containment and neutralization.

Regulatory Status

1V-LSD is a controlled substance analog research chemical in many jurisdictions, restricted to licensed scientific research and not approved for human consumption.

Frequently Asked Questions (FAQs)

1. What is the expected effect duration of 1V-LSD at 225 mcg?

• The experience typically lasts 8 to 12 hours, including peak effects and gradual comedown.

2. How potent is 1V-LSD compared to LSD?

• Approximately one-third the potency of LSD in behavioral models.

3. What are common effects at this dose?

• Intense visual hallucinations, euphoria, altered cognition, and time distortion.

4. How should 1V-LSD be stored?

• In airtight, light-resistant containers, refrigerated for long-term stability.

5. What safety precautions are necessary?

• Use standard PPE, work in ventilated areas, and follow hazardous chemical protocols.

Conclusion

1V-LSD Valerie 225 MCG is a high-purity research chemical offering potent psychedelic effects as a prodrug to LSD. It provides researchers with a unique tool to study the pharmacology, metabolic pathways, and structure-activity relationships of acylated lysergamides under controlled and safe conditions.