1V-LSD Valerie 10 MCG Micro Pellets Product Description

Introduction

1V-LSD, also known as 1-valeryl-D-lysergic acid diethylamide or “Valerie,” is a synthetic lysergamide and novel analog of LSD. It features a valeroyl (pentanoyl) group attached at the nitrogen-1 position of the lysergic acid diethylamide core. Distributed in micro pellets containing 10 micrograms each, 1V-LSD is intended for research purposes to study psychedelic mechanisms and neuropharmacology. This compound is part of a group of N-acylated LSD derivatives, believed to act as prodrugs metabolizing in vivo to LSD while potentially having their own partial agonist activity at serotonin receptors.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C25H33N3O2

• Molecular Weight: Approximately 407.55 g/mol

• CAS Number: Not widely assigned; research chemical

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-pentanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1V-LSD, Valerie, 1-Valeryl-LSD, 1-Pentanoyl-LSD

Physical Properties and Purity Standards

• Appearance: Small microdose pellets with 10 micrograms of 1V-LSD each; raw compound appears as a white to off-white crystalline powder.

• Purity: Generally ≥ 98%, consistent with research-grade standards.

• Solubility: Soluble in organic solvents such as ethanol, methanol, and acetonitrile; limited water solubility.

• Storage Recommendations: Store in airtight, light-protected containers under cool, dry conditions, preferably refrigerated to maintain potency and chemical stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1V-LSD acts mainly as a prodrug to LSD, being enzymatically converted in vivo to active LSD, which then binds and activates serotonin 5-HT2A receptors, mediating psychedelic effects. Animal studies, including the mouse head-twitch response assay, demonstrate that 1V-LSD has a potency approximately one-third that of LSD, consistent with other N-acylated lysergamides. It may also exhibit weak partial agonist activity itself at the 5-HT2A receptor.

Research Applications

Used in neuropharmacological, receptor binding, and behavioral research to explore structure-activity relationships of psychedelic compounds. The micro pellet dosing format supports precise administration in dose-response and mechanistic studies of serotonergic psychedelics.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Structurally, 1V-LSD is a higher homolog to 1P-LSD and 1B-LSD, possessing a longer pentanoyl side chain. This influences its metabolic rate and potency relative to these analogs. Like 1P-LSD and 1cP-LSD, it is thought to act predominantly as a prodrug to LSD, though with its own receptor interaction profile.

Advantages for Research

1V-LSD’s micro pellet form facilitates accurate, reproducible microdosing for research. Its unique chemical substitution expands the range of lysergamide analogs available for investigation, helping researchers understand how acyl chain length affects pharmacology and metabolism.

Safety and Handling Guidelines

Laboratory Safety

Use appropriate PPE such as gloves, eye protection, and lab coats. Handle pellets in well-ventilated laboratories or fume hoods to avoid accidental exposure by inhalation or contact. Follow all local safety regulations.

Disposal and Environmental Considerations

Dispose of residuals and waste as hazardous chemical waste following institutional protocols. Prevent environmental contamination through proper containment and neutralization.

Regulatory Status

1V-LSD is controlled under research chemical legislation in many regions and intended exclusively for scientific laboratory use. It is not approved for human consumption.

Frequently Asked Questions (FAQs)

1. What dose are 1V-LSD pellets typically?

• Pellets typically contain 10 micrograms each for precise microdosing.

2. How potent is 1V-LSD compared to LSD?

• Animal studies show around one-third the potency of LSD in head-twitch assays.

3. Does 1V-LSD have psychoactive effects on its own?

• It is mainly a prodrug for LSD but may have weak partial agonist activity.

4. How should 1V-LSD be stored?

• In airtight, light-resistant containers, kept cool and dry, preferably refrigerated.

5. Is 1V-LSD legal for research?

• It is restricted to licensed research and is not legal for human consumption in most jurisdictions.

Conclusion

1V-LSD Valerie 10 MCG Micro Pellets are high-purity, precisely dosed research chemicals representing a novel pentanoyl-substituted LSD analog. They support detailed neuropharmacological exploration of psychedelic effects, receptor dynamics, and metabolic pathways within regulated scientific settings.