1cP-LSD L-tartrate Pure Product Description

Introduction

1cP-LSD L-tartrate is the tartrate salt form of 1-cyclopropionyl-lysergic acid diethylamide (1cP-LSD), a semi-synthetic lysergamide closely related to LSD (lysergic acid diethylamide). This purified crystalline salt offers improved stability and solubility compared to the free base compound, making it appropriate for precise scientific research and analytical applications. 1cP-LSD features a cyclopropionyl group at the nitrogen-1 position, which influences its pharmacology and metabolic profile. The tartrate salt form is preferred in laboratory settings for its enhanced handling characteristics.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C24H29N3O2 (base) combined with tartaric acid

• Molecular Weight: Approximately 391.51 g/mol (free base)

• CAS Number: 2767597-50-0

• IUPAC Name: (6aR,9R)-4-(cyclopropanecarbonyl)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1cP-LSD Tartrate, 1-Cyclopropionyl LSD L-tartrate, 1-Cyclopropanoyl-LSD Tartrate

Physical Properties and Purity Standards

• Appearance: A white to off-white crystalline powder with high purity and chemical stability as a tartrate salt.

• Purity: Typically ≥ 98% purity confirming research-grade quality.

• Solubility: Significantly more soluble in water and polar solvents than the free base, as well as soluble in ethanol and methanol.

• Storage Recommendations: Store in a tightly sealed container, in a cool, dry, and dark environment, ideally refrigerated (4°C) to maintain optimal stability and minimize degradation.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1cP-LSD L-tartrate acts primarily through 5-HT2A receptor agonism, a central serotonin receptor subtype involved in psychedelic effects. Pharmacological studies indicate 1cP-LSD likely serves as a prodrug metabolized in vivo to LSD, which then activates serotonergic pathways leading to its psychoactive properties. This receptor modulation influences neural signal transduction relevant in psychedelic research and potential therapeutic mechanisms.

Research Applications

The tartrate salt form is favored in pharmacology and neurochemical research due to its enhanced solubility and stability, facilitating accurate dosing and precise analytical studies such as chromatographic profiling, receptor binding assays, and metabolic pathway investigations. It aids in evaluating ligand-receptor interactions and structure-activity relationships among lysergamide derivatives.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Compared to other LSD analogs like 1P-LSD and 1B-LSD, 1cP-LSD has a distinct cyclopropionyl substitution, affecting its pharmacokinetics and in vivo metabolism. The tartrate salt provides superior solubility and storage stability relative to free-base forms. Its close chemical relationship with LSD allows comparative studies on potency, efficacy, and metabolic activation, offering insights into prodrug behaviors within the lysergamide class.

Advantages for Research

By providing a chemically stable, highly pure, and well-soluble salt form, 1cP-LSD L-tartrate supports consistent experimental reproducibility. The compound is ideal for receptor pharmacology, solid analytical chemistry applications, and preclinical investigations into LSD analog metabolism and pharmacodynamics.

Safety and Handling Guidelines

Laboratory Safety

Use personal protective equipment such as gloves, lab coat, and eye protection when handling 1cP-LSD L-tartrate. Minimize exposure by working in well-ventilated areas or fume hoods. Avoid inhalation of dust and contact with skin and eyes.

Disposal and Environmental Considerations

Dispose of residuals and waste according to established hazardous chemical protocols, avoiding environmental release. Employ methods for chemical neutralization or compliant chemical waste disposal.

Regulatory Status

1cP-LSD L-tartrate is typically regulated as a controlled substance analog research chemical under various national laws, restricted solely to non-human scientific research with regulatory oversight and compliance.

Frequently Asked Questions (FAQs)

1. What advantages does the tartrate salt form provide?

• Enhanced solubility and chemical stability compared to free base facilitate improved lab handling.

2. Is 1cP-LSD L-tartrate more stable during storage?

• Yes, especially when kept cool, dry, and protected from light, its shelf life and purity are preserved.

3. How is 1cP-LSD L-tartrate used in pharmacological research?

• For receptor binding, metabolic pathway studies, and quantification in analytical assays.

4. Does 1cP-LSD metabolize into LSD?

• Evidence supports its function as a prodrug releasing LSD in vivo.

5. What safety precautions are vital when handling this compound?

• Use PPE, work in ventilated areas, and avoid inhalation or skin contact.

Conclusion

1cP-LSD L-tartrate presents a high-purity, stable salt form of a cyclopropionyl-modified lysergamide analog to LSD. Its superior solubility and chemical stability make it well-suited for rigorous pharmacological and analytical research into psychedelics. This compound advances understanding of lysergamide structure-activity relationships and metabolic mechanisms under strict research and safety protocols.