1cP-LSD 100 MCG Blotters Product Description

Introduction

1cP-LSD (1-cyclopropionyl-lysergic acid diethylamide) is a semi-synthetic lysergamide that acts as an acylated derivative of LSD (lysergic acid diethylamide). Delivered as 100 microgram blotters, 1cP-LSD is designed for laboratory research and analytical purposes. These blotters serve as a convenient dosage form for precise measurement and application in neuropharmacological and psychedelic research. The cyclopropionyl group attached at the nitrogen-1 position differentiates 1cP-LSD chemically and pharmacologically from LSD and related lysergamides.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Chemical Formula: C24H29N3O2
Molecular Weight: 391.51 g/mol
CAS Number: 2767597-50-0
IUPAC Name: (6aR,9R)-4-(cyclopropanecarbonyl)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Synonyms: 1cP-LSD, 1-Cyclopropionyl LSD, 1-cyclopropanoyl-lysergic acid diethylamide

Physical Properties and Purity Standards

Appearance: Thin paper blotters impregnated with precise 100 microgram doses of 1cP-LSD, typically colorless or lightly colored depending on manufacturer. The raw compound is a crystalline powder before impregnation.
Purity: High purity, typically > 95% as confirmed by HPLC analysis, meeting stringent research-grade standards.
Solubility: Soluble in organic solvents such as acetonitrile, ethanol, and methanol, with low water solubility.
Storage Recommendations: Store blotters in airtight, light-resistant packaging under cool and dry conditions, ideally refrigerated or at -20°C for long-term stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1cP-LSD acts primarily as a potent agonist at the 5-HT2A serotonin receptor subtype, which mediates the classic psychedelic effects. Pharmacological evidence from animal studies shows 1cP-LSD induces head-twitch behavior in mice, indicative of 5-HT2A receptor activation. Like other acylated lysergamides, 1cP-LSD may function as a prodrug, undergoing in vivo conversion to LSD, which then exerts the majority of the pharmacodynamic effects.

Research Applications

Used widely for neuropharmacology and receptor binding research, 1cP-LSD facilitates studies on psychedelic structure-activity relationships and metabolic pathways. The blotter format enables precise dosing in experimental designs investigating serotonergic modulation, psychedelic signaling cascades, and therapeutic potential of LSD analogs.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Chemically distinct from LSD by its cyclopropionyl substituent, 1cP-LSD compares to other N1-acylated derivatives like 1P-LSD and 1B-LSD, sharing similar affinity for serotonin receptors but differing in metabolism and potency profiles. The cyclopropionyl group is smaller and structurally rigid compared to butanoyl or propionyl groups seen in related compounds, influencing pharmacokinetics.

Advantages for Research

Blotters containing measured 100 mcg doses provide ease of administration and reliable reproducibility for dose-dependent studies. 1cP-LSD’s unique acyl modification aids investigations into prodrug behavior and receptor pharmacology. Its distinct pharmacokinetic and metabolic features compared to other lysergamides broaden the scope for comparative research.

Safety and Handling Guidelines

Laboratory Safety

Practice strict adherence to laboratory safety protocols: wear gloves, lab coat, and eye protection. Avoid direct contact or inhalation of powdered material during blotter preparation. Work in well-ventilated spaces or fume hoods.

Disposal and Environmental Considerations

Dispose of all waste material in compliance with hazardous chemical disposal regulations. Prevent environmental contamination by avoiding release into water systems or soil.

Regulatory Status

1cP-LSD is generally regulated as a research chemical under controlled substance laws in many jurisdictions and is intended exclusively for laboratory use, not for human consumption.

Frequently Asked Questions (FAQs)

1. What dosage is typical for 1cP-LSD blotters?

• Blotters commonly contain 100 micrograms for research dosing consistency.

2. How stable is 1cP-LSD on blotters?

• Stable when stored in airtight, cool, and dark conditions, refrigerated to enhance shelf life.

3. Does 1cP-LSD metabolize into LSD?

• Yes, it is believed to metabolize in vivo to LSD, acting as a prodrug.

4. What solvents dissolve 1cP-LSD?

• Soluble in acetonitrile, ethanol, and methanol; poorly soluble in water.

5. Is 1cP-LSD legal for research use?

• Subject to regional regulations; typically restricted to controlled research environments.

Conclusion

1cP-LSD 100 MCG Blotters provide a precise and reliable format for researching a cyclopropionyl substituted lysergamide analog of LSD. Their high purity and consistency support robust pharmacological, metabolic, and receptor-binding studies under regulated settings, advancing understanding of psychedelic neuropharmacology and lysergamide chemistry.