1B-LSD L-tartrate Pure Product Description

Introduction

1B-LSD L-tartrate is the tartrate salt form of 1-butanoyl-lysergic acid diethylamide (1B-LSD), a synthetic lysergamide structurally related to LSD. It is provided as a pure crystalline powder, typically intended for research use in laboratories to study serotonergic psychedelics and their neuropharmacological effects. The tartrate salt enhances the compound’s stability and solubility characteristics compared to the free base. This compound is emerging in research contexts to explore psychedelic pharmacology, metabolite profiling, and receptor binding dynamics.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Chemical Formula: C24H31N3O2 (for the base); the tartrate salt form combines with tartaric acid
Molecular Weight: Approximately 393.52 g/mol (base)
CAS Number: 2349376-12-9
IUPAC Name: (6aR,9R)-4-butanoyl-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Synonyms: 1-Butanoyl-LSD Tartrate, 1B-LSD L-tartrate, N1-butyryl-lysergic acid diethylamide tartrate

Physical Properties and Purity Standards

Appearance: Pure crystalline powder, typically white to off-white in color, with good chemical stability as a salt form.
Purity: Generally ≥ 98% pure, meeting high standards for research-grade chemicals.
Solubility: More soluble in water and polar solvents than the free base form due to formation of the tartrate salt; also soluble in organic solvents such as methanol and ethanol.
Storage Recommendations: Store in a cool, dry, and dark environment (ideally 4°C) in airtight containers to minimize degradation from moisture, heat, and light exposure.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Similar to other lysergamides, 1B-LSD L-tartrate acts primarily as an agonist at the serotonin 5-HT2A receptor, which is implicated in the modulation of psychedelic effects. Behavioral and biochemical research suggests that 1B-LSD may act as a prodrug that metabolizes in vivo to release LSD, which then interacts with 5-HT2A and other serotonin receptor subtypes. This interaction initiates intracellular signaling cascades responsible for the characteristic psychedelic responses observed in studies.

Research Applications

1B-LSD L-tartrate is used in pharmacological research to investigate receptor binding profiles, ligand structure-activity relationships, and metabolic pathways relevant to psychedelic compounds. Its stable salt form allows precise dosing and improved handling for analytical studies, including chromatographic and spectroscopic analyses. Research also includes exploring therapeutic potentials and neurophysiological effects of lysergamide analogs.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Compared with LSD, 1B-LSD exhibits reduced potency but retains similar receptor binding characteristics, attributed to the butanoyl modification at the nitrogen-1 position. The tartrate salt enhances solubility and stability over the free base. Compared to related analogs such as 1P-LSD and ALD-52, 1B-LSD has a longer acyl chain which may influence its pharmacokinetics and metabolic conversion rate.

Advantages for Research

The L-tartrate salt form offers enhanced aqueous solubility and chemical stability, making it advantageous for assay development, storage, and transport. This facilitates reproducible dosing and experimental consistency in research settings. Additionally, its unique modulation of receptor activity aids comparative studies of lysergamide psychedelics.

Safety and Handling Guidelines

Laboratory Safety

Use recommended PPE including gloves, lab coat, and eye protection when handling 1B-LSD L-tartrate. Avoid inhalation of powders and direct contact with skin. Work within a fume hood or well-ventilated area to minimize exposure risk.

Disposal and Environmental Considerations

Dispose of 1B-LSD L-tartrate waste following institutional hazardous chemical protocols and local regulations. Avoid release into environmental water sources. Dilution and chemical neutralization methods may be required.

Regulatory Status

Regulatory status varies by jurisdiction; 1B-LSD and its salts are generally classified as research chemicals with restrictions on human consumption. Compliance with all local regulatory requirements for controlled substances is mandatory.

Frequently Asked Questions (FAQs)

1. What is the difference between 1B-LSD free base and L-tartrate?
   The L-tartrate is a salt form that improves solubility and stability compared to the free base powder.

2. Is 1B-LSD L-tartrate more stable than other forms?
   Yes, the tartrate salt enhances chemical stability and shelf life, especially when stored properly.

3. How is 1B-LSD L-tartrate used in research?
   It is utilized for receptor binding studies, pharmacological assays, and metabolism investigations.

4. What storage conditions are recommended?
   Store in a cool, dry place at 4°C in airtight containers protected from light.

5. Is 1B-LSD L-tartrate legal?
   Its legal status depends on local regulations, and it is intended solely for research use.

Conclusion

1B-LSD L-tartrate pure form is a research-grade salt of a lysergamide analog structurally related to LSD. The tartrate salt enhances solubility and stability, making it suitable for precise laboratory investigations into psychedelic pharmacology and receptor interactions. Its use aids in elaborating structure-activity relationships and metabolic profiles in psychedelic science under appropriate regulatory controls and safety conditions.