1B-LSD 125 MCG Blotters Product Description

Introduction

1B-LSD, known chemically as 1-butanoyl-lysergic acid diethylamide, is a synthetic lysergamide and a structural analog of LSD (lysergic acid diethylamide). It appears as blotters impregnated with precise doses, often 125 micrograms per blotter, used in scientific research settings. The compound is part of a family of psychedelics related to LSD but modified at the nitrogen-1 position with a butanoyl group. This modification slightly alters its chemical and pharmacological profile compared to LSD itself. 1B-LSD is primarily investigated as a research chemical for laboratory and analytical purposes, especially in neuropharmacology and medicinal chemistry.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Chemical Formula: C24H31N3O2
Molecular Weight: Approximately 393.53 g/mol
CAS Number: 2349376-12-9
IUPAC Name: (6aR,9R)-4-butanoyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Synonyms: 1-Butanoyl-LSD, 1B-LSD, N1-butanoyl-lysergic acid diethylamide

Physical Properties and Purity Standards

Appearance: Typically distributed as thin paper blotters, often with a faint color or design for identification, containing the compound absorbed into the material. Pure 1B-LSD is a crystalline powder before application.
Purity: High-purity research-grade 1B-LSD is typically ≥ 98%, suitable for laboratory use with minimal impurities.
Solubility: Soluble in organic solvents such as ethanol and methanol; limited solubility in water.
Storage Recommendations: Store in a cool, dry, and dark environment in airtight containers to prevent degradation from moisture, heat, and light exposure. Stability is optimized when kept under inert conditions and away from direct sunlight.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1B-LSD acts primarily through agonism at the serotonin 5-HT2A receptor, a key receptor subtype implicated in psychedelic effects. Behavioral studies in animal models indicate 1B-LSD induces receptor-mediated head-twitch responses similar to LSD, albeit with approximately 14% of LSD’s potency. It is believed 1B-LSD may function as a prodrug, metabolizing in vivo to release active LSD, which then interacts with central nervous system receptors. This metabolic conversion suggests 1B-LSD’s effects and mechanisms overlap closely with LSD but with distinct pharmacokinetics and potency profiles.

Research Applications

As a newer lysergamide, 1B-LSD serves as a valuable tool in psychopharmacological research exploring ligand-receptor interactions, psychedelic mechanisms, and receptor signaling pathways. It aids the study of psychedelic compounds’ structural modifications and their impact on potency, receptor binding affinity, and behavioral outcomes in preclinical models. 1B-LSD’s distinct chemical structure allows comparison against LSD in efficacy, safety, and pharmacodynamics studies, informing therapeutic and neurochemical research.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

1B-LSD shares structural similarities with LSD and other N1-substituted lysergamides such as 1P-LSD (1-propionyl-LSD) and ALD-52 (1-acetyl-LSD). While LSD itself exhibits higher potency (ED50 = 132.8 nmol/kg in mice), 1B-LSD shows reduced but significant activity (~14% potency). Its longer butanoyl chain differentiates it chemically and pharmacologically from the shorter-chain 1P-LSD and ALD-52, which influences receptor affinity and metabolic conversion rates.

Advantages for Research

1B-LSD offers a unique profile in the lysergamide class, enabling detailed studies of structure-activity relationships in serotonergic psychedelics. Its potential as a prodrug mechanism expands understanding of metabolic pathways involved in these compounds. Additionally, 1B-LSD’s lower potency relative to LSD allows safer dose titration in experimental models, facilitating controlled research into psychedelics’ neurobehavioral effects.

Safety and Handling Guidelines

Laboratory Safety

Handle 1B-LSD with appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection. Avoid inhalation, ingestion, or skin contact. Work in a well-ventilated area or fume hood to prevent exposure to powders or vapors. Practice strict hygiene and wash hands thoroughly after handling.

Disposal and Environmental Considerations

Dispose of 1B-LSD waste according to institutional hazardous chemical protocols and local regulations. Dilution with water and chemical degradation may be employed. Avoid release into sewage systems or the environment to prevent ecological impact.

Regulatory Status

1B-LSD is generally categorized as a research chemical and may be subject to controlled substance regulations depending on jurisdiction. It is intended strictly for laboratory research purposes and not for human consumption. Compliance with all applicable legal and regulatory requirements is mandatory.

Frequently Asked Questions (FAQs)

1. What is 1B-LSD used for in research?
   1B-LSD is used to study psychedelic receptor interactions, pharmacology, and metabolic pathways related to lysergamides.

2. Is 1B-LSD as potent as LSD?
   No, 1B-LSD is about 14% as potent as LSD in preclinical models.

3. Does 1B-LSD metabolize into LSD?
   Research suggests 1B-LSD may act as a prodrug, converting into LSD in vivo.

4. How should 1B-LSD be stored?
   Store in a cool, dry, and dark place, in sealed containers protected from moisture and light.

5. Is 1B-LSD legal to buy?
   It depends on local laws; it is typically legal only for research and not for human use.

Conclusion

1B-LSD 125 MCG Blotters represent a research-grade lysergamide analog of LSD with distinct chemical modifications at the N1 position. Exhibiting lower potency but LSD-like properties, 1B-LSD provides valuable insight into structure-activity relationships and pharmacological mechanisms of psychedelic compounds. Its role as a potential prodrug expands opportunities for study in preclinical models and neuropharmacology, making it an important tool for advancing psychedelic research while requiring strict laboratory safety and regulatory compliance.