WITH Fumarate (N-methyl-N-ethyltryptamine) Product Description

Introduction

WITH fumarate, chemically known as N-methyl-N-ethyltryptamine fumarate, is a synthetic compound belonging to the tryptamine family. It is a fumarate salt form of N-methyl-N-ethyltryptamine (MET), which is a substituted tryptamine structurally related to other psychedelic compounds such as N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET). This compound appears as a light brown to off-white crystalline powder and is primarily utilized in research settings to study its pharmacological and psychoactive properties. The fumarate salt improves the compound’s stability and solubility for experimental applications.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C13H18N2 · C4H4O4 (fumarate salt)

• Molecular Weight: 318.4 g/mol (fumarate salt)

• CAS Number: 5599-69-9 (freebase)

• IUPAC Name: 3-[2-(ethyl(methyl)amino)ethyl]-1H-indole fumarate

• Synonyms: N-methyl-N-ethyltryptamine fumarate, MET fumarate

Physical Properties and Purity Standards

• Appearance: Light brown to off-white crystalline powder

• Purity: ≥97% research grade purity

• Solubility: Soluble in water, enhancing usability in aqueous experimental media

• Storage Recommendations: Store in a tightly sealed container in a cool, dry area, protected from light and moisture. Refrigeration or storage at -20°C recommended for long-term stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

N-methyl-N-ethyltryptamine (MET) acts primarily as a psychedelic tryptamine by interacting with serotonin receptors, especially the 5-HT2A receptor subtype, mediating altered perception, mood, and cognition. As a full agonist at 5-HT2A receptors, MET induces changes akin to classical hallucinogens by modulating serotoninergic neurotransmission. The fumarate salt form does not alter the pharmacodynamics but enhances compound stability and solubility for research.

Research Applications

MET fumarate is widely used in neuropharmacological research to investigate psychedelic and psychoactive mechanisms, receptor binding affinities, and structure-activity relationships within the tryptamine class. It is also studied for its biochemical metabolism, receptor selectivity profiles, and potential therapeutic implications related to mood and cognition modulation.

Comparative Analysis with Related Compounds

Comparison to DMT and DET

Compared to related tryptamines such as DMT (N,N-dimethyltryptamine) and DET (N,N-diethyltryptamine), MET features an asymmetrical substitution with one methyl and one ethyl group on the amine nitrogen. This unique substitution influences its binding affinity, psychoactive potency, and pharmacokinetics. While DMT is well-known for a rapid and intense psychedelic experience, MET tends to produce milder yet distinct effects, often studied for nuanced receptor interactions.

Advantages for Research

MET fumarate’s unique alkyl substitution pattern offers distinct receptor binding profiles useful in dissecting serotonin receptor signaling pathways. Its enhanced solubility in aqueous media via the fumarate salt form improves handling in biochemical assays and experimental protocols, making it a versatile tool for studying psychedelic tryptamines.

Safety and Handling Guidelines

Laboratory Safety

Handle MET fumarate with appropriate protective equipment, including gloves, laboratory coat, and eye protection. Avoid inhalation, ingestion, or contact with skin and eyes. Work within a ventilated fume hood to minimize exposure risk.

Disposal and Environmental Considerations

Dispose of MET fumarate as hazardous laboratory chemical waste according to institutional guidelines. Avoid environmental release and contamination.

Regulatory Status

MET fumarate is for laboratory research use only and is not intended for human consumption. Regulatory classification may vary, with restrictions present in some countries due to its psychoactive nature. It is essential to verify compliance with local laws before acquisition or use.

Frequently Asked Questions (FAQs)

1. What is MET fumarate used for in research?
   It is used to study psychedelic and serotonergic receptor-mediated effects in neuropharmacology.

2. How does MET differ from DMT?
   MET has one methyl and one ethyl group on the amine nitrogen, resulting in distinct receptor binding and milder psychoactive effects compared to the dimethyl-substituted DMT.

3. Is MET fumarate safe for human use?
   No, it is intended solely for research and is not approved for human consumption.

4. What is the solubility of MET fumarate?
   It is soluble in water and organic solvents, facilitating its use in various research assays.

5. How should MET fumarate be stored?
   Store in a sealed container in a cool, dry place, preferably refrigerated or frozen for long-term stability.

Conclusion

WITH fumarate (N-methyl-N-ethyltryptamine fumarate) is a significant tryptamine derivative for research with psychoactive and serotonergic receptor affinity properties. Its fumarate salt form improves physical stability and solubility, making it an important compound for neuropharmacological and biochemical experimentation. Proper handling, storage, and adherence to regulatory frameworks are essential given its potent biological activity and potential regulatory controls.