ADB-B / ADB-BUTINACA

PRODUCT DESCRIPTION

Introduction

ADB-B (also referred to as ADB-BUTINACA) is a synthetic cannabinoid compound belonging to the indazole-3-carboxamide class of cannabinoid receptor agonists. This potent compound is structurally characterized by an indazole core linked to a butyl side chain and a tert-leucinamide group. ADB-BUTINACA is primarily used in analytical and pharmacological research as a reference compound to study synthetic cannabinoid receptor interactions. It is synthesized as a crystalline solid, typically available as a freebase or salt form for laboratory use. Due to its high potency, it is of considerable interest in forensic toxicology and regulatory studies.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C18H26N4O2

• Molecular Weight: 330.43 g/mol

• CAS Number: 2682867-55-4

• IUPAC Name: N-[(1S)-1-(Aminocarbonyl)-2,2-dimethylpropyl]-1-butyl-1H-indazole-3-carboxamide

• Synonyms:

  • ADB-BUTINACA

  • ADB-BINACA (emcdca synonym)

  • ADMB-BUTINACA

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline solid

• Purity: ≥98% purity standard for research-grade substances

• Solubility: Soluble in dimethylformamide (DMF) at 20 mg/mL, dimethyl sulfoxide (DMSO) at 10 mg/mL, and ethanol at 20 mg/mL

• Storage Recommendations: Store in a cool, dry, and dark environment at temperatures ideally between 2°C to 8°C to preserve chemical stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

ADB-BUTINACA functions as a potent full agonist at cannabinoid receptors CB1 and CB2, binding with high affinity (Ki approximately 0.3 nM at CB1 and 0.9 nM at CB2). It activates these G-protein coupled receptors to modulate neurotransmission in the central nervous system, mimicking effects similar to Δ9-tetrahydrocannabinol (THC). ADB-BUTINACA is associated with dose-dependent pharmacological effects, including pronounced hypothermia in animal models, reflecting potent cannabinoid receptor stimulation.

3.2 Research Applications

ADB-BUTINACA is widely used as an analytical standard in forensic toxicology, clinical research, and pharmacological studies to detect, quantify, and understand synthetic cannabinoid receptor agonists. It is instrumental in elucidating metabolic pathways, receptor binding kinetics, and toxicological profiles of synthetic cannabinoids. Its high potency and prevalence in seized substances make it critical for regulatory and health surveillance research.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

ADB-BUTINACA is structurally related to ADB-BINACA, differing mainly in the alkyl substituent on the indazole ring (butyl vs. benzyl). It shares similarities with other potent synthetic cannabinoids such as MDMB-CHMICA, AB-FUBINACA, and JWH-018, although ADB-BUTINACA shows higher receptor affinity and efficacy. Its full agonist profile distinguishes it from partial agonists like THC.

4.2 Advantages for Research

The compound’s high affinity and full agonist properties at CB1 and CB2 receptors make it an ideal reference molecule for studying synthetic cannabinoid receptor pharmacodynamics. Its analytical availability facilitates the development of detection assays and metabolic studies critical for forensic applications.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle ADB-BUTINACA with appropriate personal protective equipment, including gloves, lab coat, and eye protection. Conduct use in a well-ventilated fume hood environment to avoid inhalation or accidental exposure due to its high potency.

5.2 Disposal and Environmental Considerations

Dispose of waste material containing ADB-BUTINACA according to local chemical hazardous waste regulations. Avoid environmental contamination by following institutional disposal protocols.

5.3 Regulatory Status

ADB-BUTINACA is regulated in many jurisdictions as a controlled synthetic cannabinoid substance. It is often classified under Schedule I or equivalent due to high abuse potential and lack of approved medical use. Verification of local regulations is essential before acquisition or research use.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of ADB-BUTINACA?
   It is approximately 330.43 g/mol.

2. What receptors does ADB-BUTINACA target?
   It is a potent full agonist at CB1 and CB2 cannabinoid receptors.

3. What research applications does ADB-BUTINACA have?
   It is used in forensic toxicology, receptor binding studies, and metabolism research.

4. What is the physical form of ADB-BUTINACA?
   Typically a white to off-white crystalline solid.

5. Is ADB-BUTINACA legally controlled?
   Yes, it is regulated in many countries under controlled substance laws.

Conclusion

ADB-B / ADB-BUTINACA is a high-potency synthetic cannabinoid agonist extensively used in research to characterize cannabis receptor pharmacology and forensic detection methodologies. Its significant receptor affinity and full agonist efficacy emphasize the need for careful handling and regulatory compliance in scientific applications.