1P-MiPLA L-tartrate Pure Product Description

Introduction

1P-MiPLA L-tartrate is the tartrate salt form of 1-propanoyl-lysergic acid methylisopropylamide (1P-MiPLA), a semi-synthetic lysergamide analog of LSD characterized by a propanoyl group at the nitrogen-1 position and an N-methyl-N-isopropylamide substitution. Offered as a pure crystalline powder in the tartrate salt form, it exhibits enhanced chemical stability and solubility compared to its free base. This compound is designed for advanced pharmacological, neurochemical, and metabolic research with a focus on psychedelic serotonergic receptor mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C23H29N3O2 (lysergamide base) combined with tartaric acid salt form

• Molecular Weight: Approximately 379.5 g/mol (free base)

• CAS Number: 3028950-73-1

• IUPAC Name: (8β)-9,10-didehydro-N,6-dimethyl-N-(1-methylethyl)-1-(1-oxopropyl)-ergoline-8-carboxamide

• Synonyms: 1P-MiPLA L-tartrate, 1-propanoyl-lysergic acid methylisopropylamide tartrate

Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder with improved stability due to tartrate salt formation.

• Purity: ≥ 98% purity, confirmed via chromatographic and spectrometric methods suitable for research applications.

• Solubility: Enhanced solubility in water and polar solvents compared to free base; also soluble in methanol and ethanol.

• Storage Recommendations: Store sealed in airtight, light-protected containers under cool, dry, and refrigerated conditions (4°C) to maintain chemical integrity.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1P-MiPLA L-tartrate likely acts as a prodrug that enzymatically converts in vivo to MiPLA, which acts as a partial agonist at serotonin 5-HT2A receptors, mediating psychedelic effects. The tartrate salt form facilitates biochemical and receptor-binding assays by enhancing solubility and compound stability, allowing investigation of ligand-receptor interactions specific to the substituted lysergamide.

Research Applications

This compound is employed in neuropharmacology, receptor binding studies, and metabolic profiling to elucidate psychedelic structure-activity relationships and prodrug metabolism pathways. The stable and soluble tartrate salt format is optimized for precise dosing and formulation in pharmacological research and assay development.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

1P-MiPLA represents a structurally unique lysergamide compared to LSD and other analogs like 1P-LSD and 1cP-MiPLA, distinguished by its N-methyl-N-isopropylamide group and shorter acyl chain. These molecular differences influence its potency, metabolic conversion, and receptor binding profile, differing from parent LSD and other acylated lysergamides both chemically and pharmacologically.

Advantages for Research

The tartrate salt enhances aqueous solubility, chemical stability, and ease of experimental handling. It allows reproducible dosing and assay accuracy while supporting investigation of novel psychedelic pharmacodynamics and metabolism associated with N1-acylated lysergamides.

Safety and Handling Guidelines

Laboratory Safety

Wear appropriate PPE including gloves, lab coat, and eye protection. Perform all handling procedures in well-ventilated areas or within fume hoods to minimize exposure risk. Avoid inhalation and contact.

Disposal and Environmental Considerations

Dispose of remaining material and waste using regulated hazardous chemical protocols, ensuring containment and environmental safety.

Regulatory Status

1P-MiPLA L-tartrate is subject to regulatory control as a research chemical analog under various legal frameworks and is intended solely for laboratory use and not human consumption.

Frequently Asked Questions (FAQs)

1. What is the function of the tartrate salt form?

• Enhances solubility and chemical stability compared to the free base.

2. Is 1P-MiPLA active or a prodrug?

• It likely functions as a prodrug metabolizing to MiPLA, which is pharmacologically active.

3. How is 1P-MiPLA L-tartrate used in research?

• For receptor binding assays, metabolism studies, and pharmacodynamics research.

4. What are the storage conditions?

• Store in sealed containers at 4°C, protected from light and moisture.

5. What safety precautions are necessary?

• Use lab PPE and handle in ventilated areas following chemical safety protocols.

Conclusion

1P-MiPLA L-tartrate is a research-grade, high-purity salt form of a substituted lysergamide designed for psychedelic neuropharmacology studies. Enhanced solubility and stability make it suited for detailed investigations into receptor interactions, metabolic pathways, and structure-activity relationships under regulated laboratory conditions.