1cP-MiPLA 200 MCG Blotters Product Description

Introduction

1cP-MiPLA, or 1-cyclopropionyl-N-methyl-N-isopropyllysergamide, is a semi-synthetic lysergamide structurally related to LSD. It features a cyclopropionyl group attached at the nitrogen-1 position and a distinctive N-methyl-N-isopropylamide substitution. Supplied as 200 microgram blotters, this compound is primarily intended for laboratory research exploring psychedelic neuropharmacology and serotonergic receptor interactions. Its unique chemical modifications set it apart from typical LSD analogs and make it valuable for investigating structure-activity relationships within the lysergamide family.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C24H29N3O2

• Molecular Weight: Approximately 391.5 g/mol

• CAS Number: 3028950-74-2

• IUPAC Name: (5R,8R)-1-cyclopropanecarbonyl-N-methyl-N-(1-methylethyl)-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinoline-8-carboxamide

• Synonyms: 1-cyclopropionyl-MiPLA, 1cP-MiPLA, 1cP-MIPLA

Physical Properties and Purity Standards

• Appearance: Thin paper blotters impregnated with 200 micrograms of high-purity 1cP-MiPLA. The pure compound is a white to off-white crystalline substance.

• Purity: Research-grade purity typically ≥ 98%, ensuring minimal impurities for valid scientific studies.

• Solubility: Soluble in organic solvents such as methanol, ethanol, and acetonitrile. Limited solubility in water.

• Storage Recommendations: Store blotters in airtight, light-resistant packaging under cool, dry conditions (ideally refrigerated) to preserve potency and stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1cP-MiPLA is believed to act as a partial agonist at the serotonin 5-HT2A receptor subtype, similar to other lysergamides. This receptor interaction is thought to mediate the psychedelic effects observed in related compounds. The presence of the cyclopropionyl moiety suggests that 1cP-MiPLA may function as a prodrug, metabolizing in vivo to MiPLA, although this is not conclusively established and remains under investigation.

Research Applications

The compound serves as a novel research tool to explore serotonergic psychedelics, receptor binding dynamics, and structure-activity relationships. Its distinctive molecular features allow the study of how substitutions at nitrogen-1 and the amide group affect ligand affinity, potency, and metabolic pathways. Microdosed blotters allow for precise dosing in pharmacological and behavioral assays.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Compared with LSD, 1cP-MiPLA has a substituted amide group (N-methyl-N-isopropyl) and a cyclopropionyl addition at N1, altering its pharmacological profile. It shares similarities with 1cP-LSD but is chemically distinct due to its amide substitutions. Early anecdotal and preclinical reports suggest it is less potent and features a shorter, less intense effect profile than LSD.

Advantages for Research

1cP-MiPLA provides a unique chemical scaffold for studying psychedelic receptor mechanisms, metabolic transformations, and dose-response relationships. Its lower potency and modified pharmacokinetics may allow safer dose escalation in experimental models. The consistent blotter formulation aids reproducibility in neuroscience and pharmacology research.

Safety and Handling Guidelines

Laboratory Safety

Adhere to strict safety practices including wearing gloves, lab coat, and eye protection. Handle blotters in well-ventilated labs or fume hoods. Avoid inhalation or direct contact with skin.

Disposal and Environmental Considerations

Dispose of all chemical waste in accordance with hazardous material guidelines. Avoid environmental release, employing chemical neutralization or compliant disposal protocols.

Regulatory Status

Often regulated as a controlled substance analog, 1cP-MiPLA is intended strictly for scientific research. It is illegal for human consumption in many jurisdictions and should only be handled under appropriate legal and safety frameworks.

Frequently Asked Questions (FAQs)

1. Is 1cP-MiPLA a prodrug?

• It is suspected to be a prodrug for MiPLA, but this remains under research without conclusive evidence.

2. How does 1cP-MiPLA compare in potency to LSD?

• It is believed to be less potent and to produce a shorter, more manageable psychedelic experience.

3. What solvents dissolve 1cP-MiPLA?

• Soluble mainly in organic solvents such as methanol, ethanol, and acetonitrile.

4. How are 1cP-MiPLA blotters stored?

• In airtight, cool, and dark conditions, preferably refrigerated.

5. Is 1cP-MiPLA legal to possess or use?

• Typically not, except for licensed scientific research due to controlled substance analog status.

Conclusion

1cP-MiPLA 200 MCG Blotters are a chemically distinct lysergamide analog with unique substitutions, used in research to elucidate psychedelic pharmacology and receptor interactions. Its structural features and prodrug potential open pathways for investigation in neuropharmacological studies under controlled laboratory and regulatory compliance.