2/3-FEA 40MG/120MG Pellets Product Description

Introduction

2/3-FEA Pellets are precision-formulated research chemicals combining two fluorinated amphetamine positional isomers: 2-Fluoroethamphetamine (2-FEA) and 3-Fluoroethamphetamine (3-FEA). These compounds are synthetic stimulants characterized by the substitution of a fluorine atom on the phenyl ring at the second (ortho) and third (meta) positions respectively, and an ethyl group on the amine nitrogen. Each pellet delivers a controlled dose of 40 mg of 2-FEA and 120 mg of 3-FEA. Designed exclusively for scientific research, these compounds are explored for their neuropharmacological effects, interaction with monoamine transporters, and behavioral pharmacology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White to off-white compact pellets containing specified doses of 2-FEA and 3-FEA.

• Purity: Both compounds generally meet or exceed 98% purity standards suitable for laboratory research.

• Solubility: Soluble in polar organic solvents including methanol, ethanol, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF); exhibit limited aqueous solubility.

• Storage Recommendations: Store pellets in airtight, opaque containers to protect from light and moisture. Ideal storage conditions include cool, dry environments, preferably refrigerated at 2-8°C to maintain stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2-FEA and 3-FEA act primarily by increasing the extracellular concentration of dopamine, norepinephrine, and serotonin through promotion of neurotransmitter release and inhibition of reuptake via monoamine transporters (DAT, NET, SERT). The precise positioning of the fluorine atom impacts their transporter affinity and potency:

• 2-FEA (Ortho-Fluoro): Mediates balanced dopaminergic and noradrenergic stimulation with moderate serotonergic activity, leading predominantly to stimulant-like effects.

• 3-FEA (Meta-Fluoro): Exhibits noticeably greater serotonin release relative to dopamine and norepinephrine, contributing to a more entactogenic profile alongside stimulation.

Both collectively produce a complex neuropharmacological response valuable in dissecting the interplay between stimulant and empathogenic activities.

Research Applications

The mixed pellet formulation is suited for detailed pharmacodynamic and behavioral studies focusing on how fluorine positional isomerism alters psychostimulant effects. Applications include receptor binding profiling, transporter kinetics, metabolism studies, and behavioral neuroscience research.

Comparative Analysis with Related Compounds

Compare the Compound(s) Often Compared To

2-FEA and 3-FEA differ structurally and functionally from each other and from non-fluorinated ethylamphetamine by fluorine substitution positional effects that influence pharmacokinetics and receptor engagement. Compared to other fluorinated amphetamines like 2-FA and 3-FA, 2/3-FEA compounds share the ethyl substitution on nitrogen, prolonging stimulant effects and modulating potency.

Advantages for Research

• Ensures controlled, reproducible dosing with combined active ingredients.

• Enables nuanced studies on structure-activity relationships via positional isomerism.

• Supports comprehensive evaluations of stimulant and entactogen receptor pharmacology in a single product.

Safety and Handling Guidelines

Laboratory Safety

Mandatory use of protective gloves, lab coats, and safety glasses is recommended. Handling should occur in well-ventilated laboratories or fume hoods to avoid inhalation and dermal exposure.

Disposal and Environmental Considerations

Chemical waste must be disposed of following institutional and governmental hazardous waste regulations. Measures to prevent environmental contamination are essential.

Regulatory Status

Classified under controlled research chemicals with licensing requirements and restrictions applicable in many jurisdictions. Use confined solely to authorized scientific research.

Frequently Asked Questions (FAQs)

1. What are the primary differences between 2-FEA and 3-FEA?

• The position of the fluorine on the phenyl ring differentiates pharmacological effects: 2-FEA is more stimulant-centric, whereas 3-FEA exhibits stronger serotonin-mediated effects.

2. What dosing does each pellet contain?

• Each pellet includes 40 mg of 2-FEA and 120 mg of 3-FEA.

3. How should the pellets be stored for optimal stability?

• Store in airtight, light-protected containers at cool temperatures (preferably refrigerated).

4. Are both compounds legal for use?

• These substances are highly regulated and restricted to licensed research contexts only.

5. What solvents can dissolve 2/3-FEA compounds?

• Effective solvents include methanol, ethanol, DMSO, and dimethylformamide.

Conclusion

The 2/3-FEA 40MG/120MG Pellets combine two fluorinated positional isomers of ethylamphetamine, providing a valuable, high-purity research chemical blend. This product facilitates advanced investigations into stimulant and empathogenic mechanisms influenced by fluorine positioning, enabling critical insights into structure-activity relationships and monoamine transporter pharmacology under stringent laboratory conditions.