Escaline Hydrochloride Product Description

Introduction

Escaline hydrochloride is the hydrochloride salt form of Escaline, a synthetic psychedelic phenethylamine derivative structurally related to mescaline and 3C-E. Escaline itself is chemically known as 2-(4-ethoxy-3,5-dimethoxyphenyl)ethanamine. The hydrochloride salt enhances its chemical stability and solubility, making Escaline hydrochloride a finely divided white crystalline solid suitable for laboratory research. The compound is used exclusively in controlled scientific research to study psychedelic properties and serotonin receptor interactions.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C12H20ClNO3

• Molecular Weight: 261.75 g/mol

• CAS Number: 3166-82-3

• IUPAC Name: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride

• Synonyms: Escaline hydrochloride, 4-ethoxy-3,5-dimethoxyphenethylamine hydrochloride

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥97% for research-grade material

• Solubility: Soluble in water, ethanol (10 mg/mL), dimethyl sulfoxide (3 mg/mL), and phosphate-buffered saline (3 mg/mL)

• Storage Recommendations: Store in airtight containers in a cool, dry place protected from light; recommended storage temperature is -20°C

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Escaline hydrochloride functions predominantly as an agonist at serotonin 5-HT2A receptors, leading to altered sensory perception, cognition, and mood characteristic of psychedelic substances. The hydrochloride salt influences compound bioavailability and provides enhanced stability without changing its pharmacodynamics.

3.2 Research Applications

Escaline hydrochloride is widely used in psychopharmacological and neurochemical research to study serotonin receptor activity, hallucinogenic mechanisms, and structure-activity relationships within the phenethylamine class. It serves as a model compound for investigating interactions with serotonergic receptors in vitro and in vivo.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Structurally related to mescaline and 3C-E, Escaline exhibits higher potency at serotonin receptors, with a chemical profile tailored to phenethylamine psychedelics. The hydrochloride salt is preferred for its superior solubility and chemical stability compared to the free base form, making it suitable for precise experimental formulation.

4.2 Advantages for Research

The hydrochloride salt form ensures accurate weighing and dosing essential for reproducible research. Its good solubility in aqueous and organic solvents facilitates a variety of bioassays and formulations, ensuring broad applicability in pharmacological research.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with appropriate personal protective equipment such as gloves, lab coat, and eye protection. Use in well-ventilated areas or fume hoods. Minimize dust generation and inhalation.

5.2 Disposal and Environmental Considerations

Dispose of in accordance with institutional hazardous waste regulations. Prevent environmental contamination by proper chemical waste management.

5.3 Regulatory Status

Escaline hydrochloride is a research chemical not approved for human use. Regulatory restrictions vary by jurisdiction. Compliance with institutional and legal regulations is essential.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of Escaline hydrochloride?
   261.75 g/mol.

2. What is the solubility of Escaline hydrochloride?
   Soluble in water, ethanol (10 mg/mL), DMSO (3 mg/mL), and PBS (3 mg/mL).

3. What receptor does Escaline hydrochloride primarily target?
   Serotonin 5-HT2A receptor.

4. How does Escaline compare to mescaline?
   Escaline is chemically related and generally exhibits greater potency.

5. What are the common research uses of Escaline hydrochloride?
   Studies of psychedelic mechanisms, serotonin receptor pharmacology, and structure-activity relationships.

Conclusion

Escaline hydrochloride is a high-purity, soluble hydrochloride salt of a potent psychedelic phenethylamine. It provides enhanced stability and solubility for research purposes focused on serotonin receptor activity and hallucinogenic pharmacology.