bk-2C-B Hydrochloride

PRODUCT DESCRIPTION

Introduction

Beta-keto-2C-B hydrochloride (bk-2C-B HCl) is the hydrochloride salt form of beta-keto-2C-B, a synthetic psychedelic phenethylamine structurally related to 2C-B but distinguished by a beta-ketone group on its side chain. This salt form enhances solubility in polar solvents and improves compound stability for research and analytical use. bk-2C-B HCl is a crystalline solid commonly used for neuropharmacology and forensic studies due to its serotonergic psychoactive properties.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C10H12BrNO3 · HCl

• Molecular Weight: 310.6 g/mol

• CAS Number: 2303508-66-7

• IUPAC Name: 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)-ethanone, monohydrochloride

• Synonyms:

  • βk-2C-B hydrochloride

  • bk-2C-B HCl

  • 2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)-ethanone hydrochloride

2.2 Physical Properties and Purity Standards

• Appearance: White crystalline solid

• Purity: Typically ≥98% for research-grade preparations

• Solubility: Approximately 2.5 mg/mL in DMSO; soluble in aqueous and polar organic solvents

• Storage Recommendations: Store at -20°C in sealed containers, protected from light and moisture to maintain purity and stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

bk-2C-B hydrochloride acts predominantly as a partial agonist at the serotonin 5-HT2A receptor and related subtypes, producing psychedelic psychoactive effects consistent with 2C-B analogues. The beta-ketone substitution affects its binding affinity and metabolic stability relative to 2C-B. Pharmacodynamic activity is mediated primarily through serotonergic pathways.

3.2 Research Applications

Used in neuropharmacological, behavioral, and forensic research to explore serotonin receptor pharmacology, metabolic pathways, and psychoactive substance profiling. The hydrochloride salt form facilitates solubility and precise dosing in experimental setups.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

bk-2C-B HCl is chemically related to 2C-B hydrochloride but with altered receptor dynamics due to the ketone moiety. Compared to other phenethylamines and β-keto analogues, it provides distinct pharmacological and pharmacokinetic profiles valuable for SAR studies. Unlike cathinones, it lacks the amphetamine backbone but should be treated with similar caution.

4.2 Advantages for Research

The hydrochloride salt form’s enhanced solubility supports accurate and reproducible in vitro and in vivo research. Its high purity and stable crystalline form allow consistent results in neurochemical and toxicological evaluations.

Safety and Handling Guidelines

5.1 Laboratory Safety

Wear appropriate protective equipment when handling bk-2C-B HCl, including gloves and eye protection. Operate in well-ventilated areas or fume hoods to prevent exposure.

5.2 Disposal and Environmental Considerations

Dispose of material in accord with hazardous chemical waste protocols. Avoid environmental contamination.

5.3 Regulatory Status

Regulatory status varies; bk-2C-B hydrochloride is controlled or regulated in several jurisdictions due to psychoactive properties. Always verify local laws before use.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of bk-2C-B hydrochloride?
   Approximately 310.6 g/mol.

2. How soluble is bk-2C-B HCl?
   Around 2.5 mg/mL in DMSO; soluble in polar solvents and aqueous mixtures.

3. What receptor does bk-2C-B primarily affect?
   It is a partial agonist at serotonin 5-HT2A receptors.

4. How does bk-2C-B hydrochloride differ from freebase?
   The salt form offers increased solubility and stability for research.

5. Is bk-2C-B hydrochloride regulated?
   Yes, restrictions vary by country; verify before handling.

Conclusion

Beta-keto-2C-B hydrochloride is a stable, soluble salt form of a psychedelic phenethylamine used extensively in serotonin receptor pharmacology research. Its defined chemical and pharmacological profiles, combined with the hydrochloride salt’s enhanced solubility, make it vital for reproducible and precise experimental work, with essential adherence to safety and regulatory standards.