3-Me-PCE HCl (3-Methyleticyclidine Hydrochloride) Product Description

Introduction

3-Me-PCE HCl, chemically known as 3-Methyleticyclidine hydrochloride, is a synthetic dissociative compound from the arylcyclohexylamine class, characterized by a methyl group substitution at the 3-position of the phenyl ring. It is a close structural analog of eticyclidine (PCE), featuring an ethylamino group attached to the cyclohexane ring. This compound is distributed as a research chemical in hydrochloride salt form with high purity and stability, intended exclusively for controlled scientific research studies. It is not approved for medical or recreational use.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder or pellets of hydrochloride salt.

• Purity: Typically ≥ 97%, verified through nuclear magnetic resonance (NMR), mass spectrometry (MS), and chromatographic techniques.

• Solubility: Soluble in polar organic solvents such as ethanol, methanol, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF); hydrochloride salt form enhances aqueous solubility.

• Storage Recommendations: Store in tightly sealed, opaque containers, refrigerated between 2°C and 8°C, away from moisture and direct light to maintain chemical integrity and stability for up to two years.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

3-Me-PCE acts as a potent antagonist of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptors integral to excitatory neurotransmission. Through this antagonism, it disrupts excitatory signaling, leading to dissociative and anesthetic effects characteristic of arylcyclohexylamines like PCP and ketamine. The methyl group substitution influences binding affinity and pharmacokinetics, potentially altering potency, duration, and toxicity compared to PCE. Emerging data suggests 3-Me-PCE may share overlapping effects with other methoxy and hydroxy analogs.

Research Applications

Used as a neuropharmacological tool to explore NMDA receptor function, dissociative anesthetic mechanisms, cognitive and behavioral effects, and metabolism. It supports forensic toxicology by serving as a reference standard for detecting novel designer dissociatives and profiling their biochemical pathways.

Comparative Analysis with Related Compounds

Compare to PCE, 3-MeO-PCE, and 3-HO-PCE

3-Me-PCE is structurally similar to PCE but introduces a methyl group at the 3-position of the phenyl ring, differentiating its receptor binding and pharmacodynamics. Compared with 3-MeO-PCE and 3-HO-PCE, it exhibits distinct receptor affinity and behavioral effects due to the nature of the substitution at the meta position. Potency and toxicity profiles vary accordingly, making it a critical compound for SAR (structure-activity relationship) research.

Advantages for Research

• Unique chemical substitution allows detailed investigation of meta-substituent effects on NMDA receptor antagonism.

• High purity and stability enable consistent experimental reproducibility.

• Valuable for forensic and pharmacological studies of emerging dissociative substances.

Safety and Handling Guidelines

Laboratory Safety

Personnel must wear lab coat, gloves, and eye protection. Handling procedures require well-ventilated environments or fume hoods to reduce exposure risks.

Disposal and Environmental Considerations

Dispose chemical waste following hazardous material guidelines. Avoid environmental exposure by using proper containment and neutralization.

Regulatory Status

3-Me-PCE HCl is controlled in many jurisdictions and restricted to licensed scientific research.

Frequently Asked Questions (FAQs)

1. What is the main mode of action of 3-Me-PCE?

• It acts primarily as an NMDA receptor antagonist producing dissociative effects.

2. What is the chemical difference between 3-Me-PCE and PCE?

• 3-Me-PCE has a methyl group at the 3-position of the phenyl ring, unlike PCE.

3. What solvents dissolve 3-Me-PCE HCl?

• Ethanol, methanol, DMSO, DMF, with improved water solubility due to hydrochloride salt.

4. Is 3-Me-PCE stable over time?

• Yes, it maintains stability for up to two years under recommended storage.

5. Is 3-Me-PCE a legal substance?

• Its use is regulated with restrictions for research purposes only.

Conclusion

3-Me-PCE HCl is a well-characterized, high-purity meta-methyl substituted eticyclidine derivative exhibiting potent NMDA receptor antagonism. It is an important compound for neuropharmacological, toxicological, and forensic research of dissociative agents, featuring chemical stability and consistent dosing in enriched scientific settings.