4C-MAR (4-Chlorine-4-methylaminorex) Product Description

Introduction

4C-MAR, also known as 4-Chloro-4-methylaminorex, is a synthetic stimulant of the substituted aminorex family. Emerging around 2021-2022, it has been identified as a novel psychoactive substance (NPS) with stimulant effects similar to 4-methylaminorex (4-MAR) but with distinct chemical and pharmacological properties conferred by the chlorine substitution at the 4-position. The compound has received attention for forensic and neuropharmacological research due to its stimulant profile.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: Crystalline solid or powder, typical of substituted aminorex derivatives.

• Purity: Minimum 99% pure for research grade, determined by NMR integration and chromatography.

• Solubility: Approximately 10 mg/mL in DMSO and phosphate buffered saline (pH 7.2).

• Storage: Store at -20°C in airtight containers protected from light, with stability for over 2 years.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4C-MAR, like other methylaminorex compounds, is a monoamine releasing agent and reuptake inhibitor, elevating synaptic dopamine, norepinephrine, and serotonin. The chlorine substitution modifies binding affinity, potency, and pharmacokinetics compared to the parent compound 4-MAR.

Research Applications

Used primarily for forensic screening of new psychoactive substances, neuropharmacological studies of stimulant mechanisms, and toxicological profiling. Stable chemical form ensures consistent dosing for scientific research.

Safety and Handling Guidelines

Laboratory Safety

Use gloves, lab coat, eye protection, and conduct handling in ventilated laboratory spaces or fume hoods.

Disposal and Environmental Considerations

Dispose chemical residues as hazardous waste according to regulations.

Regulatory Status

4C-MAR is newly emerging with varying legal status internationally, mostly controlled under analogue regulations; research use only.

Frequently Asked Questions (FAQs)

1. What is 4C-MAR chemically?

• A chlorinated derivative of 4-methylaminorex stimulant.

2. What is molecular weight?

• Approximately 210.66 g/mol.

3. What purity levels are typical?

• ≥ 99% for research-grade products.

4. What are solubility parameters?

• Soluble at 10 mg/mL in DMSO and buffered saline (pH 7.2).

5. How should it be stored?

• Refrigerated airtight containers at -20°C.

6. Is 4C-MAR legal?

• Regulated and mostly restricted to research in most regions.

Conclusion

4C-MAR is a high-purity, chemically stable novel stimulant classified as a substituted aminorex derivative with unique chlorine substitution. It is important for research into novel stimulants, forensic toxicology, and pharmacological profiling of new psychoactive substances.