Phenylpiracetam – Solution

PRODUCT DESCRIPTION

Introduction

Phenylpiracetam Solution is a liquid formulation of the synthetic nootropic compound Phenylpiracetam (Carphedon), prepared for research use. Commonly supplied as a clear liquid solution with controlled concentration, it facilitates precise dosing without the need for powder dissolution steps. Phenylpiracetam is known for enhancing cognition, memory, and physical stamina, and the solution format is preferred for in vitro assays, in vivo studies, and pharmacological experiments requiring rapid and uniform compound delivery.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C12H14N2O2C12H14N2O2

• Molecular Weight: 218.25 g/mol

• CAS Number: 77472-70-9

• IUPAC Name: 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide

• Synonyms: Carphedon, Phenotropil

Physical Properties and Purity Standards

• Appearance: Clear to pale yellow liquid solution

• Purity: Typically ≥98% pure Phenylpiracetam in solution

• Solubility: Prepared as a fully dissolved clear solution in co-solvents (e.g., DMSO, PEG300, Tween 80, water) to achieve target molarity

• Storage Recommendations: Store solution in sealed containers at 2-8°C or lower, protected from light and moisture to maintain stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

The neuropharmacological mechanism remains consistent with the pure compound, involving modulation of cholinergic and dopaminergic neurotransmission and positive allosteric modulation of glutamate receptors. The solution format ensures rapid bioavailability and uniform exposure in experimental conditions.

Research Applications

Phenylpiracetam solution is widely used for cognitive enhancement, neuroprotection, and physical performance studies. It enables convenient application in cell cultures, animal models, and behavioral experiments without solubility issues of powder forms.

Preparation and Handling of Solution

• Stock solutions of various molarities (e.g., 1 mM, 5 mM, 10 mM) can be prepared by dissolving measured milligrams of powder in appropriate volumes of DMSO or other suitable solvents.

• For in vivo formulations, the DMSO stock is typically diluted sequentially with PEG300, Tween 80, and sterile water (ddH₂O) while ensuring each step yields a clear solution before adding the next solvent.

• Physical aids like vortexing, ultrasound, or warm water bath enhance dissolving and clarity.

• Corn oil formulations can be prepared similarly by mixing DMSO stock with oil under agitation.

Comparative Analysis with Related Forms

Compare to Powder

The solution offers improved dosing accuracy, ease of use, and reproducibility in research compared to powdered Phenylpiracetam, eliminating solvent dissolution variability.

Advantages for Research

The ready-to-use transparent solution format saves preparation time and allows precise dosing critical for pharmacokinetic and pharmacodynamic studies.

Safety and Handling Guidelines

Laboratory Safety

Handle with gloves, goggles, and lab coats. Use in ventilated areas to avoid inhalation of vapors. Avoid skin contact and ingestion.

Disposal and Environmental Considerations

Dispose of solution and contaminated materials via institutional chemical waste protocols.

Regulatory Status

Available solely for research use under controlled regulations; not approved for human consumption or clinical use.

Frequently Asked Questions (FAQs)

1. What concentrations are typical for Phenylpiracetam solutions?
   Common stock solutions include 1 mM, 5 mM, and 10 mM preparations.

2. How is in vivo formulation prepared?
   DMSO stock diluted with PEG300, Tween 80, and sterile water in sequence ensuring clarity.

3. How to store Phenylpiracetam solution?
   Refrigerate at 2-8°C, protected from light.

4. Can the solution be used directly for cell culture?
   Yes, after appropriate dilution and sterility confirmation.

5. Are there risks handling the solution?
   Follow standard lab safety protocols; avoid direct contact and inhalation.

Conclusion

Phenylpiracetam Solution provides a convenient, high-purity liquid format facilitating accurate dosing and reliable application in cognitive and neuropharmacological research. Its stable formulation aids consistent experimental outcomes.