Flunitrazolam 0.25mg Blotters Product Description

Introduction

Flunitrazolam is a potent triazolo benzodiazepine derivative related to flunitrazepam and clonazolam. Flunitrazolam 0.25 mg blotters are thin, absorbent pieces of paper containing precise doses of this powerful benzodiazepine analog, ideal for accurate and reproducible dosing in controlled pharmacological research. This compound is noted for strong sedative, anxiolytic, muscle relaxant, and hypnotic effects, and is used mainly for research on GABA-A receptor modulation.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C16H12BrFN4

• Molecular Weight: 371.20 g/mol

• CAS Number: 35661-84-6

• IUPAC Name: 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-triazolo[4,3-a]benzodiazepine

• Synonyms: Flunitrazolam

2.2 Physical Properties and Blotter Specifications

• Form: Perforated blotting paper (typically 9×9 mm) infused with 0.25 mg Flunitrazolam per blotter

• Appearance: White to off-white blotters

• Purity: ≥98% pharmaceutical/research grade

• Melting Point: Approximately 245-247°C

• Solubility: Soluble in organic solvents such as ethanol and DMSO

• Storage Recommendations: Store blotters in sealed containers away from light, moisture, and heat; recommended storage temperature is 2-8°C

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Flunitrazolam enhances GABAergic neuronal inhibition by binding to the benzodiazepine site on GABA-A receptors. This results in potent anxiolytic, sedative, muscle relaxant, and hypnotic effects, with higher receptor affinity than many classical benzodiazepines.

3.2 Research Applications

Flunitrazolam blotters provide a convenient dosage form for precise dosing in pharmacological, neurochemical, and behavioral research involving benzodiazepine receptor modulation. The blotter format enables rapid administration and reproducible drug delivery in experimental models.

Safety and Handling Guidelines

4.1 Laboratory Safety

Use gloves, protective eye wear, and lab coats when handling. Avoid inhalation and skin contact. Operate in well-ventilated areas or fume hoods.

4.2 Disposal and Environmental Considerations

Dispose of according to hazardous chemical waste management guidelines to prevent environmental contamination.

4.3 Regulatory Status

Flunitrazolam is classified as a controlled research chemical, restricted to laboratory use only. Compliance with local laws is essential.

Frequently Asked Questions (FAQs)

1. What dose does each blotter contain?
   Each blotter contains 0.25 mg Flunitrazolam.

2. How soluble is Flunitrazolam?
   Soluble in ethanol and DMSO; insoluble in water.

3. What are the effects of Flunitrazolam?
   Sedative, anxiolytic, muscle relaxant, hypnotic.

4. What are the typical uses for Flunitrazolam?
   Research into benzodiazepine receptor pharmacology and CNS depression.

5. How should blotters be stored?
   Store in sealed containers at 2-8°C, protected from light and moisture.

Conclusion

Flunitrazolam 0.25 mg blotters offer a precise, high-purity dosage form for rigorous research into benzodiazepine receptor pharmacodynamics and CNS depressant effects. Their consistent dosing and stability make them invaluable in neuropharmacological and behavioral studies.