Zolpidem Belbien Hemofarm 30 Tablets Product Description

Introduction

Zolpidem Belbien Hemofarm is a pharmaceutical product containing zolpidem tartrate, marketed as 30 tablets per package. Zolpidem is a fast-acting non-benzodiazepine hypnotic medication primarily used for the short-term treatment of insomnia, especially difficulties in falling asleep or maintaining sleep. Manufactured by Hemofarm, a reputable pharmaceutical company, these tablets are designed to promote restorative sleep by acting selectively on brain receptors responsible for calming neural activity.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C19H21N3O3 · C4H4O6 (zolpidem tartrate)

• Molecular Weight: Approx. 764.9 g/mol (tartrate salt)

• CAS Number: 82626-48-0 (zolpidem tartrate)

• IUPAC Name: N,N,6-trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide tartrate

• Synonyms: Zolpidem, Zolpidem tartrate, Belbien

Physical Properties and Purity Standards

• Appearance: White to off-white film-coated oval tablets

• Strength: Each tablet contains 10 mg of zolpidem tartrate as active ingredient

• Purity: Pharmaceutical-grade purity meeting regulatory standards

• Solubility: Slightly soluble in water; soluble in methanol and ethanol

• Storage Recommendations: Store in a cool, dry place, protected from light, typically below 25°C.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Zolpidem acts on the central nervous system by enhancing the activity of gamma-aminobutyric acid (GABA) at GABA-A receptors, specifically targeting the alpha-1 subunit. This selective binding produces sedative and hypnotic effects facilitating faster sleep onset and reducing nighttime awakenings. Unlike benzodiazepines, zolpidem does not strongly affect muscle relaxation or anxiety symptoms, leading to a more focused hypnotic effect with less daytime sedation when used correctly.

Research and Therapeutic Applications

Zolpidem Belbien is prescribed for the short-term management of insomnia where sleep difficulty significantly impairs daily functioning. Its rapid onset and relatively short half-life (~2.4 hours) ensure effective sleep induction with minimal next-day residual effects. Clinically, it is used for adult patients experiencing sleep disturbances, with dosing adjustments recommended for elderly patients or those with hepatic impairment.

Comparative Analysis with Related Compounds

Comparison to Benzodiazepines

Zolpidem differs from traditional benzodiazepines by selective affinity for the GABA-A receptor’s alpha-1 subunit, conferring primarily hypnotic effects without pronounced anxiolytic or muscle relaxant properties. It shows fewer side effects such as dependence liability and cognitive impairment when administered short term under supervision.

Advantages for Patients

Zolpidem Belbien offers rapid sleep onset, improved sleep quality, and reduced nighttime awakenings with fewer side effects like next-day drowsiness compared to benzodiazepines. Its selective action and short half-life make it well-suited for short-term insomnia treatment.

Safety and Handling Guidelines

Patient Safety

Take zolpidem exactly as prescribed, immediately before bedtime, and only when able to dedicate 7-8 hours for uninterrupted sleep. Tablets should be swallowed whole, not crushed or chewed. Caution is advised in elderly patients and those with liver dysfunction, often requiring dose reduction. Avoid alcohol or CNS depressants concomitantly.

Disposal and Environmental Considerations

Unused or expired medication should be disposed of in accordance with pharmacy or institutional guidelines for pharmaceutical waste.

Regulatory Status

Zolpidem is a controlled substance in many jurisdictions requiring prescription and medical oversight due to potential dependence and misuse. Belbien Hemofarm tablets comply with pharmaceutical regulation standards for prescription hypnotics.

Frequently Asked Questions (FAQs)

1. What is the recommended dose of Zolpidem Belbien Hemofarm?
   Adults typically take 10 mg at bedtime; elderly or liver-impaired patients may start at 5 mg.

2. How fast does Zolpidem work?
   It has a rapid onset, usually producing sleep within 15-30 minutes after ingestion.

3. Can zolpidem be used long-term?
   No, it is intended for short-term use (2-4 weeks) due to risks of tolerance and dependence.

4. What should be avoided while taking zolpidem?
   Avoid alcohol, CNS depressants, and activities requiring full alertness like driving.

5. What are common side effects?
   Drowsiness, dizziness, headache, and rarely, complex sleep behaviors such as sleepwalking.

Conclusion

Zolpidem Belbien Hemofarm 30 tablets provide a pharmaceutical-grade therapeutic option for the short-term treatment of insomnia. Its selective mechanism targeting GABA-A receptors offers effective sedation with a favorable safety profile when used appropriately. Manufactured by Hemofarm, these tablets deliver consistent dosing and rapid symptom relief for patients struggling with sleep onset or maintenance difficulties. Proper administration, storage, and adherence to prescribing information optimize treatment benefit while minimizing risks.