Temazepam 10mg 30 Tablets Product Description

Introduction

Temazepam 10mg tablets are a prescription medication belonging to the benzodiazepine class, primarily used for the short-term treatment of severe or debilitating insomnia. The tablets contain 10 mg of temazepam as the active ingredient and are designed to aid patients who experience difficulty falling asleep, frequent nighttime awakenings, or restless sleep. Temazepam works as a hypnotic by calming the brain’s increased activity and promoting restful, prolonged sleep.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C16H13ClN2O2

• Molecular Weight: 300.74 g/mol

• CAS Number: 846-50-4

• IUPAC Name: 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

• Synonyms: Temazepam, Restoril (brand name), Benzodiazepine hypnotic

Physical Properties and Purity Standards

• Appearance: White to off-white, oval, film-coated tablets

• Strength: 10 mg of temazepam per tablet

• Purity: Pharmaceutical grade conforming to quality and safety standards

• Solubility: Slightly soluble in water; soluble in methanol and ethanol

• Storage Recommendations: Store in a tightly closed container in a cool, dry place away from direct light, at temperatures between 20°C to 25°C

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Temazepam acts by enhancing the effect of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, at the GABA-A receptor complex. This potentiation results in sedation, muscle relaxation, anxiolysis, and anticonvulsant effects. Its hypnotic actions promote sleep initiation and reduce nighttime awakenings, helping restore normal sleep architecture over short-term use. The onset of action typically occurs within 30 minutes, with effects lasting 7 to 8 hours.

Therapeutic Applications

Temazepam 10mg is indicated for the management of severe, disabling insomnia, including difficulties with sleep onset and frequent awakenings. It may also be used as a premedication to relieve anxiety prior to medical or dental procedures. Due to its potential for tolerance, dependence, and withdrawal, it is generally prescribed for short durations (2 to 4 weeks).

Comparative Analysis with Related Compounds

Temazepam provides longer-lasting hypnotic effects than short-acting zolpidem and is preferred for maintaining sleep in cases of frequent awakenings.

Safety and Handling Guidelines

Patient Safety

Take temazepam exactly as prescribed at bedtime. Do not consume alcohol or other CNS depressants concurrently. Avoid activities requiring alertness, such as driving, until fully aware of the drug’s effects. Use for short durations as chronic use increases risk of dependency and withdrawal symptoms. Dose adjustments may be necessary in elderly or hepatic-impaired patients.

Disposal and Environmental Considerations

Unused medication should be returned to pharmaceutical take-back programs or disposed of per local regulations to prevent environmental contamination and misuse.

Regulatory Status

Temazepam is a controlled substance, regulated under law due to potential for abuse and dependency. Prescription and medical supervision are mandatory.

Frequently Asked Questions (FAQs)

1. What conditions does Temazepam 10mg treat?
   It is used to treat severe insomnia and difficulties with sleep initiation and maintenance.

2. How long does Temazepam last?
   Effects last approximately 7 to 8 hours, suitable for nighttime use.

3. Can Temazepam be used long term?
   No, it is generally recommended for use of 2 to 4 weeks due to tolerance risks.

4. Are there side effects?
   Common side effects include drowsiness, dizziness, headache, and confusion.

5. Can I drive after taking Temazepam?
   No, operating vehicles or machinery should be avoided until fully alert.

Conclusion

Temazepam 10mg tablets provide an effective and well-established hypnotic treatment for severe insomnia with a duration suitable for maintaining sleep through the night. Clinical use requires adherence to prescribed dosing and duration limits to minimize risks of dependence and adverse effects. Proper storage and regulatory compliance ensure safe therapeutic outcomes.