Semax Spray

PRODUCT DESCRIPTION

Introduction

Semax Spray is a synthetic heptapeptide formulation designed for research use, typically delivered via nasal spray technology. It is derived from a fragment of the adrenocorticotropic hormone (ACTH), specifically amino acids 4 to 10, with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Semax is utilized extensively in neuroscience research due to its neuroprotective, nootropic, and neurorestorative properties. The spray presents Semax in a stable, reconstituted form suitable for experimental models simulating neurological conditions, cognitive studies, and neurodegeneration. It appears as a clear or slightly opalescent aqueous solution optimized for nasal administration in laboratory settings.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C3737H5151N99O1010S

• Molecular Weight: 813.9 g/mol

• CAS Number: 80714-61-0

• IUPAC Name: (not typically assigned for peptides, sequence: Met-Glu-His-Phe-Pro-Gly-Pro)

• Synonyms: Synthetic ACTH(4-10) analog, Semax peptide

Physical Properties and Purity Standards

• Appearance: Freeze-dried white powder reconstituted to a clear aqueous spray solution

• Purity: ≥98% (HPLC purity standards for research use)

• Solubility: Soluble in water and phosphate-buffered saline (PBS) at about 10 mg/mL, also soluble in dimethyl sulfoxide (DMSO) at ~5 mg/mL, and dimethylformamide (DMF) at 1 mg/mL

• Storage Recommendations: Store lyophilized powder at -20°C for long-term storage; reconstituted spray solutions should be refrigerated and used within 24 hours for optimal stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Semax functions by modulating multiple neurobiological pathways, most notably by increasing brain-derived neurotrophic factor (BDNF) expression in regions such as the hippocampus. BDNF plays a vital role in neuronal survival, synaptic plasticity, and cognitive function. Additionally, Semax has been shown to regulate the expression of neurotransmitters and potentially exhibits melanocortin receptor interactions. It demonstrates neuroprotective effects in various ischemic and neurodegenerative disease models, along with anxiolytic and analgesic properties observed in preclinical research.

Research Applications

Semax Spray is primarily used in scientific experiments to study stroke models, global ischemia, cognitive impairment, and neurodegenerative disorders. Researchers employ it to investigate mechanisms underlying neuroprotection, memory enhancement, anxiety reduction, and recovery after neural injury. Its nasal spray formulation allows investigation of intranasal delivery routes for peptide-based therapeutics in experimental models.

Comparative Analysis with Related Compounds

Comparison with Selank and Other Nootropic Peptides

Semax differs from Selank, another synthetic peptide, mainly in amino acid sequence and targeted pharmacological pathways; Semax is primarily an ACTH fragment analog, while Selank is a tuftsin derivative. Semax has a distinct profile emphasizing BDNF upregulation and neuroprotection, whereas Selank is more associated with anxiolytic and immune-modulating properties.

Advantages for Research

The nasal spray formulation of Semax facilitates non-invasive administration in laboratory animals and models simulating human intranasal drug delivery. Its chemically stable lyophilized form enhances reproducibility and convenience in experimental protocols targeting cognitive function and neuroprotection.

Safety and Handling Guidelines

Laboratory Safety

Handle Semax Spray with appropriate personal protective equipment to avoid skin and eye contact, as it may cause irritation. Use in well-ventilated areas, avoid inhalation and ingestion, and follow institutional safety protocols for peptides and lab chemicals.

Disposal and Environmental Considerations

Dispose of Semax waste according to hazardous chemical guidelines; prevent environmental contamination by following established procedures for pharmaceutical residues.

Regulatory Status

Semax is classified as a research chemical and is not approved for human therapeutic use. Regulatory status varies by jurisdiction, often limited to experimental and research settings due to its bioactive nature.

Frequently Asked Questions (FAQs)

1. What is Semax used for in research?
   Semax is used primarily to explore neuroprotective effects, cognitive enhancement, and recovery models after brain injury.

2. How is Semax administered in research settings?
   It is commonly administered via intranasal sprays to mimic potential non-invasive delivery to the brain.

3. What are the storage requirements for Semax?
   Store lyophilized Semax at -20°C. The aqueous spray form should be refrigerated and used quickly.

4. What solvents is Semax soluble in?
   Semax is soluble in water, PBS, DMSO, and DMF at varying concentrations suitable for research solutions.

5. Is Semax approved for medical use?
   Semax is used exclusively for research and is not approved or intended for therapeutic use in humans.

Conclusion

Semax Spray is a highly purified synthetic heptapeptide research compound designed for intranasal delivery in experimental neuroscience. Its ability to upregulate BDNF, provide neuroprotection, and enhance cognitive processes makes it a crucial tool in preclinical models of brain injury and neurodegenerative diseases. The stable spray formulation allows for replicable dosing and study of peptide delivery methods, with strict laboratory handling and regulatory compliance necessary for its research use.