PRO-LAD 175 MCG Blotters

PRODUCT DESCRIPTION

Introduction

PRO-LAD (6-propyl-6-nor-lysergic acid diethylamide) is a lysergamide compound, structurally related to LSD, known for its psychedelic effects mediated by serotonin 5-HT2A receptor agonism. It has a propyl substitution at the 6-position on the ergoline ring, distinguishing it from other lysergamide analogs such as LSD and ETH-LAD. PRO-LAD typically comes in the form of blotters dosed at 175 micrograms (mcg) for research in psychopharmacology, neuropharmacology, and behavioral sciences to study psychedelic effects and receptor activity.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Molecular Formula: C22H29N3OC22H29N3O

• Molecular Weight: 351.49 g/mol

• CAS Number: 65527-63-1

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-propyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: PRO-LAD, N-Propyl-Norlysergic Acid Diethylamide, 6-propyl-6-nor-LSD, RVR83

Physical Properties and Purity Standards

• Appearance: Typically impregnated on absorbent blotter paper

• Purity: Generally ≥95% pure for research-grade compound prior to blotter impregnation

• Storage Recommendations: Store blotters in airtight, light-resistant containers at low temperature (4°C or below) to retain potency and prevent degradation

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

PRO-LAD exerts psychedelic effects primarily via agonistic activity at serotonin 5-HT2A receptors, similar to LSD and other lysergamides. The propyl substitution modulates binding affinity and pharmacokinetics, resulting in a distinct potency and duration profile. PRO-LAD induces head twitch response in animal models, correlating to hallucinogenic activity.

Research Applications

Used in behavioral pharmacology and psychedelic research to explore consciousness, receptor function, and neuropsychological effects of lysergamides. It serves as a tool for understanding structure-activity relationships within the ergoline family and comparative studies with other classical psychedelics.

Comparative Analysis with Related Compounds

Compare to Related Compounds

PRO-LAD is structurally similar to LSD but is less potent and metabolically distinct due to its propyl substitution at the 6 position instead of the methyl group. Compared to AL-LAD and ETH-LAD, PRO-LAD shows lower potency and differing metabolism, potentially acting partially as a prodrug.

Advantages for Research

PRO-LAD offers a unique chemical and pharmacological profile within the lysergamide class, aiding in precise receptor affinity studies and psychedelic effect comparisons, especially focusing on subtle structural modifications.

Safety and Handling Guidelines

Laboratory Safety

Handle blotters with gloves, avoiding skin contact and inhalation. Store securely to prevent accidental ingestion. Use in controlled laboratory settings.

Disposal and Environmental Considerations

Dispose blotters and contaminated materials as hazardous waste. Follow institutional safety protocols.

Regulatory Status

PRO-LAD is a research chemical not approved for medical or human use and is regulated under controlled substance laws in many countries.

Frequently Asked Questions (FAQs)

1. What is the typical dose of PRO-LAD on blotters?
   175 micrograms per blotter for research purposes.

2. How does PRO-LAD differ from LSD?
   It has a propyl group substitution at position 6 vs. methyl in LSD, altering potency and metabolism.

3. How should blotters be stored?
   In airtight, light-resistant containers, refrigerated or frozen for longevity.

4. Is PRO-LAD legal for human consumption?
   No, it is strictly for research use.

5. What research is PRO-LAD used for?
   Psychedelic effect analysis, receptor binding studies, and neuropharmacology.

Conclusion

PRO-LAD 175 MCG blotters provide a precise, controlled dosage of a lysergamide research chemical with distinctive psychedelic properties. Its unique chemistry supports detailed scientific investigations into serotonergic psychedelics under regulated laboratory conditions.