Oxiracetam

PRODUCT DESCRIPTION

Introduction

Oxiracetam is a synthetic nootropic compound belonging to the racetam family, distinguished by its cognitive-enhancing properties. It generally appears as a white to off-white crystalline solid and is used predominantly in research to study cognition and neuroprotective mechanisms. Oxiracetam is a 4-hydroxy analog of piracetam, and while its precise mechanism of action is not fully understood, it is believed to modulate glutamatergic and cholinergic neurotransmission, possibly involving protein kinase C pathways. It has been studied for its ability to improve memory, learning, and cognitive function, especially in conditions involving cerebral insufficiency.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C6H10N2O3C6H10N2O3

• Molecular Weight: 158.16 g/mol

• CAS Number: 62613-82-5

• IUPAC Name: 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide

• Synonyms: CGP 21690E, ISF 2522, Neurome, Olaxitam, Olacetam, Neuractiv, CGP 21690

Physical Properties and Purity Standards

• Appearance: White to off-white crystalline solid

• Purity: Typically ≥98% pure for research-grade

• Solubility: Slightly soluble in DMSO and methanol when heated; soluble in water

• Storage Recommendations: Store sealed in a dry environment at room temperature or desiccated at -20°C to maintain stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Oxiracetam is thought to exert its nootropic effects by modulating glutamatergic neurotransmission, enhancing synaptic plasticity, and increasing acetylcholine release. It may also influence protein kinase C activity in the hippocampus, supporting learning and memory processes. These effects collectively contribute to improved cognitive function and neuroprotection.

Research Applications

Oxiracetam is widely studied in models of cognitive impairment, neurodegenerative diseases, and cerebral insufficiency. Research includes its effects on learning, memory enhancement, neuroprotection against hypoxic or ischemic events, and its biochemical pathways within the central nervous system.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Oxiracetam is chemically related to other racetams such as piracetam and aniracetam but is noted for its faster onset and slightly stronger cognitive effects. Compared to piracetam, it has higher potency and bioavailability. Its 4-hydroxy substitution differentiates its pharmacodynamic profile.

Advantages for Research

Oxiracetam’s favorable absorption, CNS penetration, and relatively low toxicity make it an advantageous compound for researching cognitive enhancers and neuroprotective agents. It provides a useful model for studying cholinergic and glutamatergic modulation in neurological research.

Safety and Handling Guidelines

Laboratory Safety

Use appropriate PPE including gloves, lab coat, and eye protection when handling Oxiracetam. Avoid inhaling powders and minimize skin contact. Handle in a well-ventilated environment.

Disposal and Environmental Considerations

Dispose of according to hazardous chemical waste protocols. Avoid environmental contamination.

Regulatory Status

Oxiracetam is classified for research use only and is not approved as a clinical drug in many jurisdictions. Compliance with local research chemical regulations is necessary.

Frequently Asked Questions (FAQs)

1. What is Oxiracetam used for in research?
   It is used to study cognitive enhancement, neuroprotection, and neurotransmitter modulation.

2. How soluble is Oxiracetam?
   Slightly soluble in DMSO and methanol when heated; soluble in water.

3. What are its storage requirements?
   Store dry and sealed at room temperature or refrigerated at -20°C.

4. How does Oxiracetam differ from Piracetam?
   Oxiracetam has a 4-hydroxy group and exhibits stronger nootropic effects with faster action.

5. Is Oxiracetam safe to handle?
   Standard lab safety precautions are adequate.

Conclusion

Oxiracetam is a well-characterized nootropic compound providing potent cognitive enhancement and neuroprotective effects. Its chemical and pharmacological profile supports broad research use in neuroscience and pharmacology.