Norflurazepam 5 MG Pellets

PRODUCT DESCRIPTION

Introduction

Norflurazepam is a chemical compound belonging to the benzodiazepine class of organic compounds. It typically appears as white to off-white pellets, used commonly in research settings. Norflurazepam is a metabolite of flurazepam and related drugs. It features a fused benzene and 1,4-azepine ring structure, characteristic of 1,4-benzodiazepines. It does not have direct marketed pharmaceutical uses but is relevant in scientific and pharmacological research for understanding benzodiazepine metabolism and actions.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C15H10ClFN2OC15H10ClFN2O

• Molecular Weight: 288.70 g/mol

• CAS Number: 2886-65-9

• IUPAC Name: 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

• Synonyms: Norfludiazepam, N-desalkylflurazepam, N-desalkyl-2-oxoquazepam

Physical Properties and Purity Standards

• Appearance: White to off-white pellets or powder form

• Purity: ≥99% pure typical for research grade

• Solubility: Slightly soluble in water (approx. 0.019 g/L), more soluble in organic solvents

• Storage Recommendations: Store in a cool, dry environment away from light, tightly sealed to maintain stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Norflurazepam is a benzodiazepine derivative that acts primarily on the gamma-aminobutyric acid (GABA) receptor complex in the central nervous system. It enhances the effect of GABA, an inhibitory neurotransmitter, by increasing GABA receptor affinity, leading to neuronal hyperpolarization and reduced excitability.

Research Applications

Norflurazepam is primarily used in pharmacological and toxicological studies to understand benzodiazepine metabolism, receptor binding characteristics, and effects on the central nervous system. It serves as a reference in drug metabolism studies, particularly in the assessment of benzodiazepine-related substances and their metabolites.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Norflurazepam is closely related to flurazepam and quazepam, sharing structural characteristics but differing in metabolic transformation and receptor affinity. Compared to flurazepam, norflurazepam is an active metabolite with a longer half-life, making it significant in understanding prolonged benzodiazepine effects.

Advantages for Research

Norflurazepam’s stability and well-defined chemical profile allow for precise studies on benzodiazepine pharmacokinetics and pharmacodynamics. Its distinct identity as a metabolite supports its utility in differentiating metabolic pathways and effects among benzodiazepines.

Safety and Handling Guidelines

Laboratory Safety

Handle Norflurazepam with appropriate personal protective equipment such as gloves, lab coat, and eye protection. Avoid inhalation, ingestion, or direct skin contact. Use in well-ventilated areas with appropriate containment to prevent exposure.

Disposal and Environmental Considerations

Dispose of Norflurazepam waste according to local regulations for chemical and pharmaceutical substances. Avoid release into the environment. Follow institutional guidelines on hazardous chemical disposal.

Regulatory Status

Norflurazepam is a controlled substance in many jurisdictions due to its relation to benzodiazepines. It is typically available only for research purposes with appropriate licensing and permits.

Frequently Asked Questions (FAQs)

1. What is Norflurazepam used for in research?
   It is used to study benzodiazepine metabolism, receptor interaction, and central nervous system effects.

2. Is Norflurazepam the same as Flurazepam?
   No, Norflurazepam is a metabolite of Flurazepam with distinct chemical and pharmacological properties.

3. How should Norflurazepam be stored?
   In a cool, dry, and dark place, tightly sealed to avoid degradation.

4. Can Norflurazepam be dissolved in water?
   It has low solubility in water but higher solubility in organic solvents.

5. Is Norflurazepam safe to handle?
   It requires standard laboratory safety procedures to minimize exposure risks.

Conclusion

Norflurazepam 5 MG Pellets represent a critical chemical entity for research into benzodiazepine pharmacology and metabolism. With well-characterized chemical and physical properties, it supports investigative studies focused on receptor interactions and metabolite profiling under controlled laboratory conditions.