F-Phenibut HCL (4-Fluorophenibut Hydrochloride) Product Description

Introduction

F-Phenibut HCL is the hydrochloride salt form of 4-Fluorophenibut (β-(4-fluorophenyl)-GABA), a fluorinated analog of Phenibut. This compound is a synthetic GABAergic agent known for its high affinity for GABA-B receptors. The hydrochloride salt improves solubility and stability compared to the free base. F-Phenibut HCL appears as a white crystalline powder and is utilized exclusively in research to study GABAergic neurotransmission, anxiolytic mechanisms, and neuropharmacology.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C10H13ClFNO2

• Molecular Weight: 233.67 g/mol

• CAS Number: 1858241-03-8

• IUPAC Name: 4-fluorophenyl-gamma-aminobutyric acid hydrochloride

• Synonyms: 4-Fluorophenibut hydrochloride, F-Phenibut hydrochloride, β-(4-Fluorophenyl)-GABA HCL

2.2 Physical Properties and Purity Standards

• Appearance: White crystalline powder

• Purity: Typically ≥98% for research-grade material

• Solubility: Soluble in solvents such as DMSO, ethanol, methanol, and partially soluble in water

• Storage Recommendations: Stable for up to 3 years at -20°C, 2 years at 4°C, and short term at room temperature; store in airtight containers away from moisture and light

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

F-Phenibut HCL acts as a potent agonist at the GABA-B receptor, enhancing inhibitory neurotransmission and producing anxiolytic, muscle relaxant, and neuroprotective effects in research models. The fluorine substitution increases receptor affinity compared to phenibut, leading to greater potency and potential for intoxication in experimental settings.

3.2 Research Applications

This compound is utilized in neuropharmacological research to investigate GABA-B receptor mechanisms, anxiolytic drug pathways, and neuroprotective effects. It is a model compound in receptor binding assays and behavioral pharmacology studies focusing on GABAergic modulation.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

F-Phenibut HCL shows higher GABA-B receptor affinity and potency relative to Phenibut hydrochloride and other GABA analogs like baclofen and tolibut. The fluorine atom modifies pharmacokinetic and pharmacodynamic properties, providing enhanced effects in research models.

4.2 Advantages for Research

The hydrochloride salt form offers improved solubility crucial for in vitro and in vivo study formulations. The high purity and chemical stability contribute to reproducible experimental results. Its potent receptor activity supports studies requiring smaller dosages and precise pharmacological characterizations.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle F-Phenibut HCL with gloves, goggles, and protective clothing. Use in a ventilated area to minimize inhalation and prevent skin contact.

5.2 Disposal and Environmental Considerations

Dispose of according to hazardous chemical waste protocols. Avoid environmental contamination.

5.3 Regulatory Status

F-Phenibut HCL is a controlled research chemical with no approved clinical use. Legal status varies by country; strict regulatory compliance is required for research use.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of F-Phenibut HCL?
   C10H13ClFNO2.

2. What is its molecular weight?
   233.67 g/mol.

3. Is F-Phenibut HCL soluble in water?
   Partially soluble; better solubility observed in DMSO, ethanol, or methanol.

4. What receptor does F-Phenibut HCL target?
   The GABA-B receptor.

5. What are common research uses for this compound?
   Neuropharmacological studies on GABAergic receptor activity, anxiolytic investigations, receptor binding assays.

Conclusion

F-Phenibut HCL is a high-purity white crystalline hydrochloride salt of a fluorinated GABA-B receptor agonist. It is valuable for detailed neuropharmacological research into anxiolytic and inhibitory neurotransmission mechanisms with enhanced potency compared to Phenibut.