DMXE (Deoxymethoxetamine) Product Description

Introduction

DMXE, or Deoxymethoxetamine, is a synthetic research chemical classified within the arylcyclohexylamine chemical family—structurally related to compounds like methoxetamine (MXE) and ketamine. It appears as a white crystalline powder designed exclusively for laboratory and scientific research to investigate its pharmacological properties. DMXE’s chemical structure represents a combination of methoxetamine and 2′-ethylaminorex elements, creating a unique molecular profile that influences central nervous system receptors. It is not intended for human consumption and is handled in controlled research environments.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H21NO

• Molecular Weight: 231.33 g/mol

• CAS Number: 2666932-45-0

• IUPAC Name: 2-(ethylamino)-2-(3-methylphenyl)cyclohexan-1-one

• Synonyms: 3D-MXE, 3-Me-2′-oxo-PCE, 2′-Oxo-PCE, Deoxymethoxetamine

2.2 Physical Properties and Purity Standards

• Appearance: White crystalline powder

• Purity: Typically ≥97% (laboratory-grade)

• Solubility: Soluble in polar solvents such as ethanol, methanol, and water; slightly soluble in non-polar solvents

• Storage Recommendations: Store in a cool, dry, and dark environment, preferably in airtight containers to avoid degradation; stable for up to two years when stored correctly

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

DMXE acts primarily as a dissociative anesthetic and psychoactive substance influencing the N-methyl-D-aspartate (NMDA) receptor as an antagonist. By inhibiting the NMDA receptor, DMXE modulates glutamatergic neurotransmission, resulting in altered sensory perception and dissociative effects. It shows affinity for various central nervous system targets including dopamine transporters, influencing locomotion and behavior in preclinical models.

3.2 Research Applications

DMXE is utilized in research to study dissociative mechanisms in the brain, receptor binding, and structure-activity relationships among arylcyclohexylamine derivatives. It serves as a model compound for exploring the effects of NMDA receptor antagonists, with implications in anesthetic research, neuropharmacology, and sensory processing studies. Research also investigates its potential cognitive, behavioral, and neurochemical impacts.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

DMXE is structurally similar to methoxetamine and other arylcyclohexylamines but differs by the “deoxy” substitution, altering its pharmacokinetic and pharmacodynamic properties. Compared to MXE, DMXE exhibits nuanced receptor interaction profiles and metabolism, providing a research alternative in dissociative substance studies. Its lower molecular weight relative to some analogs facilitates easier crystallization and handling.

4.2 Advantages for Research

DMXE’s chemical stability and high purity standards contribute to reproducible results. Its unique receptor binding profile offers novel insights into NMDA antagonism compared to ketamine and MXE. The powder form allows flexibility in experimental setups, including in vitro receptor assays and in vivo pharmacology models.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use protective gloves, lab coat, and safety goggles when handling DMXE powder. Employ fume hood conditions to avoid inhalation or aerosol exposure. Avoid contact with skin and eyes; wash thoroughly if contact occurs.

5.2 Disposal and Environmental Considerations

Dispose of DMXE following institutional chemical waste disposal protocols. Avoid releasing into wastewater or environment to minimize ecological impact.

5.3 Regulatory Status

DMXE is a research chemical restricted to laboratory use and not approved for human consumption. Regulatory control varies by jurisdiction; researchers must comply with applicable laws and institutional guidelines governing experimental substances.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of DMXE?
   231.33 g/mol.

2. How stable is DMXE?
   It remains stable for up to two years under correct storage conditions.

3. What is the primary receptor target of DMXE?
   The NMDA receptor, acting primarily as an antagonist.

4. What is the standard purity of research-grade DMXE?
   Typically ≥97%.

5. In what research fields is DMXE commonly used?
   Studies on dissociative mechanisms, neuropharmacology, and NMDA receptor function.

Conclusion

DMXE (Deoxymethoxetamine) is a white crystalline arylcyclohexylamine research chemical known for its dissociative properties mediated through NMDA receptor antagonism. With a stable molecular structure and broad research applications in neuropharmacology, DMXE is a valuable compound for studying the neurochemical basis of anesthesia, cognition, and sensory modulation.