Bromantane – Solution

PRODUCT DESCRIPTION

Introduction

Bromantane solution is a liquid formulation of bromantane, a synthetic adamantane derivative known for its unique stimulant, anxiolytic, and adaptogenic effects. Provided as a clear or slightly opalescent solution, this form facilitates precise dosing for research applications, including neurochemical, pharmacokinetic, and behavioral studies. Bromantane is valued for enhancing mental and physical endurance with fewer side effects associated with classical stimulants.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C16H20BrN

• Molecular Weight: 306.24 g/mol

• CAS Number: 87913-26-6

• IUPAC Name: N-(4-bromophenyl)adamantan-2-amine

• Synonyms:

  • Bromantan

  • Ladasten

  • 2-(4-Bromophenyl)aminoadamantane

2.2 Physical Properties and Purity Standards

• Appearance: Clear to slightly opalescent liquid solution

• Purity: ≥98% purity typical for research-grade solutions

• Solubility: Stable in solvents such as dimethyl sulfoxide (DMSO), ethanol, polyethylene glycol 300 (PEG 300), and Tween 80 emulsifier for solution preparation

• Storage Recommendations: Store tightly sealed at 4°C to -20°C, protected from light and moisture to maintain stability

Preparation Method and Concentrations

Typical stock solutions prepared for research:

• 1 mg/mL, 5 mg/mL, or 10 mg/mL concentration stock solutions in solvents such as DMSO

• Subsequent dilution into aqueous vehicles containing PEG300 and Tween 80 to form clear, injectable or oral formulations

• Protocols include sequential solvent mixing with agitation and temperature control to ensure complete dissolution and homogeneity

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Bromantane increases dopamine synthesis and modulates GABAergic neurotransmission. Its stimulant effects enhance physical endurance and mental focus without typical amphetamine-like overstimulation. The adaptogenic properties contribute to reduced physical and mental fatigue.

3.2 Research Applications

Liquid bromantane solutions are used extensively in pharmacodynamic and pharmacokinetic research, behavioral experiments on fatigue and cognition, and studies of neuroprotective mechanisms. Solutions enable versatile dosing routes including oral, intranasal, and injectable in animal and in vitro studies.

Comparative Analysis with Related Compounds

4.1 Compare to Similar Compounds

Bromantane solution differs from powdered or tablet forms by ease of accurate dosing and rapid bioavailability. Compared to classical stimulants, bromantane shows lower toxicity and minimal addiction potential. It is distinct from amantadine or memantine in potency and anxiolytic profile.

4.2 Research Advantages

Solution form improves dosing precision and facilitates various administration routes. Stability in common solvents ensures reproducibility in laboratory experiments. Facilitates advanced kinetic studies and dose-response research.

Safety and Handling Guidelines

5.1 Handling

Use gloves, eye protection, and lab coat in ventilated environments. Avoid inhalation of vapors and direct skin contact when handling solutions.

5.2 Disposal

Dispose of solutions in chemical waste approved containers. Follow hazardous waste regulations.

5.3 Regulatory Considerations

Bromantane is regulated or monitored in certain regions. Ensure compliance with relevant legal frameworks before purchase or use.

Frequently Asked Questions (FAQs)

1. What bromantane solution concentrations are commonly prepared?
   1 mg/mL to 10 mg/mL stock solutions.

2. What solvents are used for preparing bromantane solutions?
   DMSO, ethanol, PEG 300, Tween 80 emulsifiers.

3. What are the storage conditions for bromantane solution?
   Refrigerate at 4°C or freeze at -20°C away from light.

4. Applications of bromantane solution in research?
   Pharmacokinetics, behavioral studies, neuroprotection research.

5. Is bromantane solution stable in common solvents?
   Yes, stable in DMSO, ethanol, PEG 300, and related solvents.

Conclusion

Bromantane solution is a highly pure, versatile liquid research chemical offering precise dosing and broad experimental utility for CNS stimulant and adaptogen studies. Adherence to safe handling procedures and regulatory compliance is essential for research applications.