Aniracetam

PRODUCT DESCRIPTION

Introduction

Aniracetam is a synthetic nootropic compound belonging to the racetam family, widely studied and used for its potential cognitive-enhancing and neuroprotective effects. It is chemically classified as an acetamide derivative and exhibits anxiolytic and antidepressant properties. Aniracetam is typically supplied as a crystalline solid, which can be formulated into powders or capsules for research purposes. It is known for its fast onset and short half-life relative to other racetams.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C12H13NO3

• Molecular Weight: 219.24 g/mol

• CAS Number: 72432-10-1

• IUPAC Name: 1-(4-methoxybenzoyl)pyrrolidin-2-one

• Synonyms:

  • Aniracetam

  • Memodrin

  • RO 13-5057

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: ≥98% purity typical for research-grade preparations

• Solubility: Soluble in organic solvents such as ethanol, DMSO; approximately 2.47 mg/mL water solubility

• Storage Recommendations: Store in a cool, dry place at room temperature or below 25°C, protected from light and moisture to maintain stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Aniracetam acts primarily as a positive allosteric modulator of AMPA-type glutamate receptors (AMPAkine). This modulation enhances synaptic transmission and plasticity, promoting improved cognitive function. It also influences cholinergic and dopaminergic systems and exhibits anxiolytic effects possibly via serotonergic pathways. Metabolites such as N-anisoyl-GABA contribute to the compound’s pharmacological activity.

3.2 Research Applications

Used extensively in neuroscience research, aniracetam serves as a tool to investigate cognition, memory, and neuroplasticity mechanisms. It is studied for therapeutic potential in neurodegenerative diseases such as Alzheimer’s disease and vascular dementia, as well as mood disorders. Its rapid metabolism makes it suitable for pharmacokinetic studies.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

Aniracetam is structurally related to piracetam and other racetams but differs due to the anisoyl substitution, conferring lipophilicity and faster onset. Compared to piracetam, aniracetam exhibits greater potency in cognitive enhancement and anxiolysis. Unlike noopept and pramiracetam, aniracetam modulates glutamate receptors more directly.

4.2 Advantages for Research

Aniracetam’s unique mechanism offers distinct insights into glutamatergic modulation compared to traditional cholinergic-centric nootropics. Its high purity and proven pharmacodynamic profile enable consistent in vitro and in vivo research with clinical relevance.

Safety and Handling Guidelines

5.1 Laboratory Safety

Wear standard PPE such as gloves, lab coats, and goggles while handling aniracetam powder. Use in a well-ventilated laboratory or fume hood to avoid airborne exposure.

5.2 Disposal and Environmental Considerations

Dispose of aniracetam following chemical waste regulations. Avoid environmental contamination.

5.3 Regulatory Status

Aniracetam is approved for medical use in some countries but remains a research chemical in others. Confirm local regulatory compliance before acquisition or use.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of aniracetam?
   C12H13NO3.

2. What receptors does aniracetam modulate?
   Primarily AMPA glutamate receptors as a positive allosteric modulator.

3. What are the main effects of aniracetam?
   Cognitive enhancement, anxiolytic, and potential antidepressant effects.

4. How soluble is aniracetam?
   Soluble in ethanol, DMSO; low solubility in water (approx. 2.47 mg/mL).

5. Is aniracetam approved for medical use?
   Approved in some countries, treated as research chemical in others.

Conclusion

Aniracetam is a high-purity, synthetic nootropic with promising cognitive and anxiolytic pharmacology through AMPA receptor modulation. It facilitates research into neurodegenerative diseases and cognitive disorders, with well-established chemical stability and safety measures essential for laboratory use.