aMT (Alpha-Methyltryptamine)

PRODUCT DESCRIPTION

Introduction

Alpha-Methyltryptamine (aMT) is a synthetic psychedelic and stimulant compound belonging to the substituted tryptamine family. It features a tryptamine backbone with a methyl group attached to the alpha carbon adjacent to the amine, structurally related to neurotransmitters such as serotonin. aMT was initially developed as an antidepressant in the 1960s and briefly marketed in the Soviet Union under brand names like Indopan. It appears as a fine crystalline solid or powder commonly used in research to investigate psychoactive and neurochemical properties.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C11H14N2

• Molecular Weight: 174.24 g/mol

• CAS Number: 7795-52-0

• IUPAC Name: 1-(1H-indol-3-yl)propan-2-amine

• Synonyms:

  • Alpha-methyltryptamine

  • aMT

  • Indopan (historical brand)

2.2 Physical Properties and Purity Standards

• Appearance: White crystalline powder or fine solid

• Purity: ≥98% for research-grade material

• Solubility: Poorly soluble in water; soluble in alcohols and organic solvents such as methanol and DMSO

• Storage Recommendations: Store in a cool, dry, light-protected environment at -20°C to preserve stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

aMT acts as a releasing agent of serotonin, dopamine, and norepinephrine and as a serotonin receptor agonist. It modulates central nervous system activity by stimulating monoaminergic pathways, producing psychedelic, stimulant, and entactogenic effects. aMT additionally exhibits weak monoamine oxidase inhibitor (MAOI) activity, contributing to its prolonged effects and potentiation of serotonergic neurotransmission.

3.2 Research Applications

aMT is used primarily in neurochemical and behavioral pharmacology research to explore tryptamine-related psychedelic mechanisms and stimulant effects. It serves as a reference compound in receptor binding studies, monoamine release assays, and metabolic profiling. Its unique pharmacodynamic profile informs studies on antidepressant and hallucinogenic agents.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

aMT shares structural similarity with other substituted tryptamines such as α-ethyltryptamine (αET), N,N-dimethyltryptamine (DMT), and 5-methoxy derivatives (5-MeO-DMT). Compared to DMT, aMT has longer duration and oral activity due to alpha-methylation and MAOI effects. It is distinct from phenethylamines by its indole backbone, aligning it more closely with serotonergic hallucinogens.

4.2 Advantages for Research

The compound’s longer half-life and monoamine releasing profile facilitate extended neuropharmacological experimentation. High purity forms ensure consistent and accurate results in mechanistic studies and receptor pharmacology. aMT’s combination of stimulant and hallucinogenic properties offers a unique investigational tool.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use appropriate personal protective equipment including gloves and eye protection. Work in a ventilated space or fume hood to avoid inhalation. Prevent skin contact and accidental ingestion.

5.2 Disposal and Environmental Considerations

Dispose of according to hazardous chemical waste protocols; avoid environmental contamination. Adhere to local regulations for disposal.

5.3 Regulatory Status

aMT is regulated as a controlled substance in numerous regions due to its psychoactive properties. Researchers must confirm compliance with jurisdictional laws before handling or procurement.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of aMT?
   C11H14N2.

2. What are the primary effects of aMT?
   Psychedelic, stimulant, and entactogenic effects via monoamine release and serotonin receptor agonism.

3. Is aMT orally active?
   Yes, due to alpha-methylation and weak MAOI activity.

4. What is the duration of aMT’s effects?
   Typically lasts between 8 to 12 hours.

5. Is aMT a controlled substance?
   Yes, regulated in many countries.

Conclusion

Alpha-Methyltryptamine (aMT) is a high-purity synthetic tryptamine with potent psychedelic and stimulant actions. Its unique pharmacology makes it a valuable research chemical in receptor studies, neurochemistry, and behavioral pharmacology with necessary safety and legal compliance.