5-MMPA

PRODUCT DESCRIPTION

Introduction

5-MMPA, also known as 5-Methylmethiopropamine or mephedrene, is a synthetic research chemical classified within the substituted thiophene and amphetamine-like stimulant family. It is a structural analog of methiopropamine distinguished by a methyl substitution at the 5-position of the thiophene ring. Commonly encountered as a hydrochloride salt in powder or crystalline form, 5-MMPA has gained attention in scientific and forensic research for its stimulant properties and chemical behavior. It is primarily used for experimental purposes and is not intended for human consumption.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C9H15NS – HCl

• Molecular Weight: 205.7 g/mol

• CAS Number: 2743746-59-8

• IUPAC Name: N,α,5-trimethyl-2-thiopheneethanamine monohydrochloride

• Synonyms:

  • 5-Methylmethiopropamine

  • Mephedrene

  • 5-MMPA hydrochloride

2.2 Physical Properties and Purity Standards

• Appearance: Off-white to pale yellow crystalline powder

• Purity: ≥98% for research grade material

• Solubility: Soluble in dimethyl sulfoxide (DMSO), dimethylformamide (DMF), ethanol, and phosphate-buffered saline (PBS) at pH 7.2; approximate solubility ranges from 1 to 20 mg/mL depending on the solvent

• Storage Recommendations: Store at -20°C in a sealed container, protected from light and moisture to maintain compound integrity

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

5-MMPA functions as a stimulant by acting primarily as a releasing agent and reuptake inhibitor of monoamine neurotransmitters, particularly dopamine and norepinephrine. It shares pharmacodynamic properties typical of substituted amphetamines and thiophene analogs, promoting increased neurotransmitter release and blocking reuptake, which results in stimulant and euphoric effects. Limited receptor binding data suggest it may also affect serotonergic systems to a minor extent, but its primary activity is dopaminergic and noradrenergic.

3.2 Research Applications

5-MMPA is employed in forensic toxicology and pharmacology research to study novel synthetic stimulants and their metabolic pathways. It is used to evaluate stimulant potency, receptor interactions, and metabolic fate within biological systems. The compound provides a valuable model for understanding the effects and metabolism of emerging synthetic cathinones and amphetamine analogs.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

5-MMPA is structurally similar to methiopropamine (MPA) but differs by the presence of a methyl group on the thiophene ring, which impacts its pharmacokinetic and pharmacodynamic profile. Unlike classic substituted cathinones such as mephedrone, 5-MMPA lacks the β-ketone group, aligning it more closely with substituted amphetamines. It is often compared to related stimulants like α-PVP and MDPV but exhibits different receptor interaction profiles and metabolic pathways.

4.2 Advantages for Research

Its distinct chemical structure offers a useful tool for dissecting structure-activity relationships among synthetic stimulants. The compound’s high purity and characterized solubility facilitate reproducible in vitro and in vivo experimentation. As a reference standard, 5-MMPA aids in forensic identification and pharmacological characterization of emerging designer drugs.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle 5-MMPA with standard laboratory precautions including personal protective equipment such as gloves, lab coats, and safety glasses. Utilize well-ventilated spaces or fume hoods when handling powders or solutions. Avoid inhalation, ingestion, and prolonged skin contact.

5.2 Disposal and Environmental Considerations

Dispose of waste materials containing 5-MMPA according to institutional and regulatory chemical waste protocols. Prevent contamination of water sources and soil. Use designated hazardous waste collection methods.

5.3 Regulatory Status

5-MMPA is not universally controlled but may be subject to regulation in some jurisdictions due to its structural similarity to controlled stimulants. Verify local legal status prior to procurement or research use.

Frequently Asked Questions (FAQs)

1. What is the chemical formula of 5-MMPA?
   The chemical formula is C9H15NS – HCl.

2. What is the primary pharmacological activity of 5-MMPA?
   It primarily acts as a stimulant affecting dopamine and norepinephrine systems.

3. What forms does 5-MMPA come in?
   It is commonly supplied as a hydrochloride salt powder or crystalline solid.

4. How soluble is 5-MMPA in common solvents?
   It is soluble in DMSO, DMF, ethanol, and PBS with solubility varying from 1 to 20 mg/mL.

5. Is 5-MMPA controlled by law?
   Its regulatory status varies; confirm local laws before handling.

Conclusion

5-Methylmethiopropamine (5-MMPA) is a high-purity synthetic stimulant research chemical, useful for investigating the pharmacology and metabolism of emerging psychoactive substances. Its chemical stability and defined solubility make it practical for forensic and pharmacological research, provided appropriate safety and regulatory guidelines are followed.