5-MeO-MiPT Hydrochloride

PRODUCT DESCRIPTION

Introduction

5-MeO-MiPT hydrochloride is the hydrochloride salt form of 5-Methoxy-N-methyl-N-isopropyltryptamine, a synthetic psychedelic tryptamine compound. It is commonly supplied as a solid crystalline powder or pelletized form, often standardized for research dosing purposes. As the hydrochloride salt, this form is typically more stable and water-soluble compared to its freebase counterpart, facilitating use in various laboratory and pharmacological assays. 5-MeO-MiPT hydrochloride has drawn scientific interest due to its psychoactive tryptamine structure featuring a 5-methoxy substitution on the indole ring.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H23ClN2O

• Molecular Weight: 282.81 g/mol

• CAS Number: 96096-55-8 (base form); hydrochloride salt form includes chloride

• IUPAC Name: 3-[2-(Methyl(isopropyl)amino)ethyl]-5-methoxy-1H-indole monohydrochloride

• Synonyms:

  • 5-MeO-MiPT HCl

  • 5-Methoxy-N-methyl-N-isopropyltryptamine hydrochloride

  • N-Isopropyl-N-methyl-5-methoxy-1H-indole-3-ethanamine hydrochloride

2.2 Physical Properties and Purity Standards

• Appearance: Off-white to light orange crystalline powder or solid pellets

• Purity: Generally ≥98% purity for research grade preparations

• Solubility: Soluble in water and polar solvents; freely soluble compared to freebase

• Storage Recommendations: Store in a cool (-20°C), dry place protected from light and moisture to sustain stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

5-MeO-MiPT hydrochloride acts as a serotonergic agonist primarily targeting 5-HT2A receptors, which are responsible for mediating psychedelic effects. It also shows affinity for other serotonin receptor subtypes such as 5-HT1A and 5-HT2B, contributing to a broad serotonergic modulation. In addition, it moderately inhibits serotonin and norepinephrine reuptake in neuronal synapses, adding complexity to its psychoactive profile. Its hydrochloride form does not significantly alter receptor dynamics but improves compound solubility for experimental delivery.

3.2 Research Applications

The hydrochloride salt of 5-MeO-MiPT is widely utilized in receptor binding studies, neurochemical pharmacology, and psychedelic research models. Its solubility in aqueous media makes it suitable for both in vitro assays and in vivo administration in experimental pharmacology. It is particularly useful for probing serotonin receptor subtype interactions and downstream signal transduction pathways associated with tryptamine-derived psychedelics.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

5-MeO-MiPT hydrochloride is closely related to freebase 5-MeO-MiPT, as well as analogs like 5-MeO-DiPT and 5-MeO-DMT. Compared to its freebase, the hydrochloride form offers enhanced aqueous solubility and chemical stability, which are advantageous for experimental consistency. Compared to 5-MeO-DiPT, it has a different substitution pattern resulting in distinct receptor binding affinities and pharmacokinetics.

4.2 Advantages for Research

The hydrochloride salt form ensures consistent dosing through increased solubility and stability, reducing variability in research outcomes. This form is preferred in laboratory settings where precise aqueous dosing and formulation are required, thus facilitating experimental reproducibility and compliance with pharmacological protocol standards.

Safety and Handling Guidelines

5.1 Laboratory Safety

When handling 5-MeO-MiPT hydrochloride, it is essential to wear appropriate personal protective equipment including gloves, lab coats, and eye protection. Conduct operations in a well-ventilated laboratory or fume hood environment. Avoid inhalation, ingestion, or unprotected skin contact. Use tools for handling powdered or pelletized forms to minimize exposure.

5.2 Disposal and Environmental Considerations

Chemical wastes containing 5-MeO-MiPT hydrochloride must be disposed of in accordance with institutional and governmental hazardous waste regulations. Avoid environmental discharge and ensure waste is collected in appropriate containment prior to disposal according to safety protocols.

5.3 Regulatory Status

Like its freebase form, 5-MeO-MiPT hydrochloride is subject to varying legal status internationally. It may be regulated as an analog under controlled substances acts in some regions. Users should verify current legislation at the local and national level before handling or procurement.

Frequently Asked Questions (FAQs)

1. What is the difference between 5-MeO-MiPT freebase and hydrochloride?
   The hydrochloride salt is more water-soluble and chemically stable, while freebase is less soluble and often in pellet form.

2. What is the molecular weight of 5-MeO-MiPT hydrochloride?
   The molecular weight is approximately 282.81 g/mol due to the addition of the hydrochloride group.

3. How should 5-MeO-MiPT hydrochloride be stored?
   Store at -20°C in a dry, light-protected environment.

4. What research applications is 5-MeO-MiPT hydrochloride used for?
   It is used mainly for serotonin receptor studies and psychedelic pharmacology research.

5. Is 5-MeO-MiPT hydrochloride controlled by law?
   Regulatory status varies by country; check local laws before use.

Conclusion

5-MeO-MiPT hydrochloride is a crystalline salt form of the tryptamine 5-MeO-MiPT, optimized for enhanced solubility and stability in research applications. It presents a versatile and reliable tool for serotonergic receptor pharmacology studies, particularly within psychedelic research contexts. Proper laboratory safety and regulatory due diligence are essential when handling this compound.