2C-E Product Description

Introduction

2C-E (2,5-Dimethoxy-4-ethylphenethylamine) is a synthetic psychedelic phenethylamine that belongs to the 2C family of compounds. It was first synthesized by Alexander Shulgin and documented in his book PiHKAL. 2C-E is characterized by the presence of methoxy groups at the 2 and 5 positions and an ethyl group at the 4 position of the phenyl ring. It is commonly used in scientific research to study psychedelic pharmacology and neuropsychopharmacology. It typically exists as a free base or hydrochloride salt and is often supplied as a crystalline solid or powder.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: Colorless to off-white crystalline powder or hydrochloride salt.

• Purity: Research-grade 2C-E is typically ≥ 98% pure.

• Solubility: Soluble in organic solvents such as ethanol, methanol, DMSO; soluble in water at concentrations above 70 mg/mL at room temperature.

• Storage Recommendations: Store in airtight containers protected from light and moisture, preferably refrigerated at temperatures between 2°C and 8°C for stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2C-E acts predominantly as an agonist at serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, which mediates its psychedelic effects. It has high affinity and potency at these serotonin receptor subtypes, resulting in altered perception, cognition, and mood. Unlike many stimulant compounds, 2C-E shows negligible monoamine releasing or reuptake inhibition activity. Activation of 5-HT2A receptors in particular is thought to contribute to its hallucinogenic properties.

Research Applications

2C-E is widely used in neuropharmacological studies to investigate the mechanisms of psychedelic action, particularly in relation to serotonin receptor pharmacology. Researchers also utilize 2C-E to study the dose-response characteristics and behavioral effects of phenethylamine psychedelics in animal and human models. Its well-defined receptor profile makes it valuable for exploring therapeutic potentials and risks associated with serotonin receptor agonists.

Comparative Analysis with Related Compounds

Compare to 2C-B and other 2C Compounds

Compared to 2C-B, 2C-E has an ethyl group rather than a bromine atom at the 4 position of the phenyl ring. This substitution results in more potent and longer-lasting psychedelic effects with a steeper dose-response curve. 2C-E is regarded as more intense and less recreational, producing vivid and often complex hallucinations. It generally has a longer duration and more pronounced cognitive effects compared to other 2C family members like 2C-I and 2C-T-7.

Advantages for Research

• Provides a distinct chemical scaffold for probing serotonin receptor-mediated psychedelic mechanisms.

• High receptor selectivity facilitates understanding of structure-activity relationships.

• Useful in dose-effect studies and behavioral pharmacology with reliable reproducibility.

Safety and Handling Guidelines

Laboratory Safety

Proper PPE including gloves, lab coat, and protective eyewear is essential. Handle in well-ventilated areas or chemical fume hoods to avoid inhalation or dermal exposure. Due to its potency and psychoactivity, care should be taken to avoid accidental exposure.

Disposal and Environmental Considerations

Dispose of wastes and residues in accordance with local regulations for hazardous chemical disposal. Prevent environmental contamination by appropriate containment and neutralization measures.

Regulatory Status

2C-E is regulated in many countries due to its potent psychedelic properties and potential for abuse. Its legal status varies, often classified under controlled substance analog acts or specific drug listings. It is intended solely for scientific research and not for human consumption.

Frequently Asked Questions (FAQs)

1. What is the typical research dosage of 2C-E?

• 2C-E is active in low milligram ranges (commonly 10-25 mg) during research.

2. How long do the effects of 2C-E last?

• Effects typically last between 8 to 12 hours.

3. What receptors does 2C-E primarily bind to?

• It primarily binds and activates serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor subtypes.

4. How does 2C-E differ from 2C-B?

• 2C-E contains an ethyl group at the 4-position instead of bromine, enhancing potency and duration.

5. What safety precautions are recommended in handling 2C-E?

• Use PPE, avoid inhalation and skin contact, handle in ventilated conditions, and observe proper disposal protocols.

Conclusion

2C-E is a potent synthetic psychedelic phenethylamine with significant serotonin receptor activity. It serves as an important compound for scientific research into psychedelic pharmacology, receptor dynamics, and behavioral effects, supporting advancements in neuropsychopharmacology under strict laboratory and regulatory controls.