2-FEA (2-Fluoroethamphetamine) Product Description

Introduction

2-Fluoroethamphetamine (2-FEA) is a synthetic stimulant belonging to the amphetamine class, characterized by a fluorine atom substituted at the second position of the aromatic ring and an ethyl group attached to the amino nitrogen. It is a fluorinated analog of ethylamphetamine, and the fluorine substitution alters its pharmacological properties. 2-FEA appears as a crystalline powder and is primarily used for scientific research purposes to study stimulant effects and related neurochemical mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C11H16FN

• Molecular Weight: 181.25 g/mol

• CAS Number: 3823-29-8

• IUPAC Name: 1-(2-fluorophenyl)propan-2-amine

• Synonyms: 2-Fluoroethamphetamine, 2-FEA, o-Fluoroethamphetamine, 2-Fluoroethyl Amphetamine

Physical Properties and Purity Standards

• Appearance: Typically a white to off-white crystalline solid.

• Purity: Research chemicals usually maintain ≥ 98% purity.

• Solubility: Soluble in organic solvents including methanol, ethanol, DMSO, and DMF; low solubility in water.

• Storage Recommendations: Store in cool, dry conditions below -20°C in airtight containers to prevent degradation.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2-FEA acts as a central nervous system stimulant, increasing the release and inhibiting the reuptake of dopamine and norepinephrine, enhancing extracellular concentrations of these neurotransmitters. Fluorination affects lipophilicity and blood-brain barrier penetration, influencing stimulant potency and duration relative to ethylamphetamine.

Research Applications

Used primarily in laboratories to investigate neuropharmacological stimulant activity, neurotransmitter release mechanisms, and structure-activity relationships among substituted amphetamines. It serves as a model compound to explore the impact of fluorine substitution on the pharmacological profile of ethylated amphetamines.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

2-FEA differs from 2-fluoroamphetamine by the ethyl group at the amine nitrogen, increasing molecular weight and potentially altering pharmacokinetics and potency. Compared to ethylamphetamine, fluorination may enhance CNS penetration and modify metabolic stability but comprehensive data remain limited.

Advantages for Research

The unique chemical structure allows evaluation of how ethyl substitution combined with fluorination influences stimulant effects. Its moderate potency and distinctive metabolic profile make it valuable in designing safer and more selective stimulant analogs.

Safety and Handling Guidelines

Laboratory Safety

Use appropriate PPE including gloves, lab coats, and eye protection. Conduct all manipulations in fume hoods or well-ventilated labs to avoid inhalation or dermal exposure.

Disposal and Environmental Considerations

Dispose of chemical waste in compliance with hazardous material protocols. Prevent environmental contamination by proper containment and neutralization.

Regulatory Status

2-FEA is controlled or regulated in many jurisdictions due to its stimulant properties and potential for abuse. It should be used only with appropriate licensing and strictly for scientific research.

Frequently Asked Questions (FAQs)

1. What distinguishes 2-FEA from other amphetamines?

• Presence of fluorine at position 2 on the phenyl ring and an ethyl group on the amine nitrogen.

2. How does fluorination affect stimulant properties?

• It often increases lipophilicity and blood-brain barrier permeability, affecting potency and duration.

3. What solvents best dissolve 2-FEA?

• Methanol, ethanol, DMSO, and DMF are effective solvents.

4. How should 2-FEA be stored?

• Stored below -20°C in airtight containers, shielded from moisture and light.

5. Is 2-FEA legal?

• Subject to regulation or control; only approved for licensed research.

Conclusion

2-Fluoroethamphetamine (2-FEA) is a fluorinated ethyl-substituted amphetamine research chemical offering distinct stimulant pharmacology. Its chemical modifications provide a useful tool for investigating dopaminergic and noradrenergic system modulation, structure-activity relationships, and potentially safer stimulant development, under controlled scientific and regulatory conditions.